Dr Francis Stephens
Associate Professor


Research interests

Research interests are centred on the influence of nutrition, physical activity, and physical inactivity on the regulation of human skeletal muscle metabolism. Particular expertise in organising and conducting prolonged (months) experimental (nutrition and exercise) interventions in heathly young and older participants, as well as patients with type 2 diabetes, combined with detailed nutritional physiology assessment. For example, measurement of insulin and amino acid sensitivity by utilising complex glucose clamp protocols with lipid and stable isotope tracer infusions, muscle biopsies and limb substrate balance that include ex vivo analysis of intermediary metabolism in human skeletal muscle.



Research projects

Nutritional strategies to improve exercise performance and recovery. BeachBody Inc. July 2016 – June 2020 (PI - Dr Francis Stephens). 

Determination of the time-course of development of insulin resistance, and associated molecular and muscular adaptations, during inactivity in prolonged bed-rest. BBSRC. March 2016 – September 2018 (Co-I, PI Prof Ian Macdonald, University of Nottingham). 

Skeletal muscle physiology and function across the nutritional spectrum: a pilot study in Crohn’s disease and nonalcoholic fatty-liver disease. BSPGHAN/CORE. October 2015 – May 2017 (Co-I, PI Dr Gordon Moran, University of Nottingham).

Increasing skeletal muscle carnitine content to improve glycaemic control in individuals recently diagnosed with Type 2 diabetes. Diabetes UK. September 2014 – October 2017 (PI – Dr Francis Stephens). 

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