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Professor Francis Stephens
Professor
2157
Richards Building RB113
Richard's Building, University of Exeter, St Luke's Campus, Heavitree Road, Exeter, EX1 2LU, UK
Office hours: Tutorial times Mondays and Fridays 12pm - 1pm.
Overview
I’m fascinated by how our muscles metabolise nutrients when we are physically active and inactive, and why these processes become perturbed as we age or develop diseases such as type 2 diabetes. My PhD and post-doctoral position at The University of Nottingham highlighted for the first time the role of muscle carnitine availability in the regulation of skeletal muscle fat and carbohydrate metabolism in humans. I was then awarded a 5-year Research Councils UK (RCUK) Academic Research Fellowship in Molecular Nutrition in 2008 to investigate the molecular pathways underpinning these observations and determine how they change with age and type 2 diabetes. During this time, I was a key member of the Medical Research Council (MRC)/Arthritis Research UK (ARUK) Centre for Musculoskeletal Ageing Research. I moved to Exeter in 2016 and was promoted to Professor of Exercise Physiology and Metabolism in 2019. My muscle metabolism work has led to the development of various sports nutrition products, which I am conducting research on at present within the newly refurbished state-of-the-art Nutritional Physiology Research Unit. Together with Professor Benjamin Wall, I lead a vibrant Nutritional Physiology Group (https://sshs.exeter.ac.uk/research/integrativephysiology/nutritionalphysiology/) with several Research Fellows, post-doctoral scientists, and post-graduate students. I have authored original peer-reviewed research and review articles in international journals, and several book chapters on skeletal muscle metabolism. I have also been invited to present at numerous international nutrition and physiology conferences and have advised on sports nutrition supplementation studies for elite athletes.
Links
Research
Research interests
Skeletal muscle insulin sensitivity
A reduction in skeletal muscle insulin sensitivity occurs with age and obesity and is a major risk factor for type 2 diabetes, one of the biggest health concerns in the developed world. Current projects are focused on how human skeletal muscle becomes insulin resistant, inflexibility in the ability to switch between fat, carbohydrate, and protein metabolism, and the role of carnitine with age, obesity and overfeeding, type 2 diabetes. I am also developing nutritional strategies to reverse the loss of insulin sensitivity with L-carnitine and novel protein and fibre combinations.
Physical inactivity
A major contributor to the reduction in insulin sensitivity (insulin resistance) in the above conditions is physical inactivity and a loss of muscle mass, which also has implications in healthy conditions such as space flight and recovery from injury. Current research is determining the time-course of development of insulin resistance, and associated molecular and muscular adaptations, during inactivity with bed-rest, limb immobilisation, and injury.
Nutritional strategies to improve exercise performance and recovery from exercise
Detailed understanding of how our muscles metabolise nutrients during various type of exercise provides insight into how fat, carbohydrate, and protein metabolism can be manipulated to improve exercise performance. Current research is utilising such scientific evidence to develop L-carnitine, protein and polyphenols, caffeine, ß-alanine, and polyphenols, mycoprotein, and nucleotides.
In vivo physiology techniques
The research described above requires expertise in conducting prolonged (months) experimental (nutrition and exercise) interventions in human volunteers and patients combined with detailed in vivo human physiology measurements utilizing stable isotopic tracer techniques, doppler ultrasound, calorimetry, hyperinsulinaemic glucose clamps, MRI and MRS, and ex vivo molecular, metabolic, and imaging analyses of human muscle biopsy samples.
Links
Publications
Journal articles
Stephens FB, Shannon CE, Ghasemi R, Greenhaff PL (In Press). Increasing skeletal muscle carnitine availability does not alter the adaptations to high-intensity interval training. Scandinavian Journal of Medicine and Science in Sports
Pavis GF, Iniesta RR, Roper H, Theobald HE, Derbyshire EJ, Finnigan TJA, Stephens FB, Wall BT (2024). A four-week dietary intervention with mycoprotein-containing food products reduces serum cholesterol concentrations in community-dwelling, overweight adults: a randomised controlled trial. Clinical Nutrition, 43(3), 649-659.
Monteyne AJ, Falkenhain K, Whelehan G, Neudorf H, Abdelrahman DR, Murton AJ, Wall BT, Stephens FB, Little JP (2024). A ketone monoester drink reduces postprandial blood glucose concentrations in adults with type 2 diabetes: a randomised controlled trial. Diabetologia, 1-7.
Shur NF, Simpson EJ, Crossland H, Constantin D, Cordon SM, Constantin-Teodosiu D, Stephens FB, Brook MS, Atherton PJ, Smith K, et al (2024). Bed-rest and exercise remobilization: Concurrent adaptations in muscle glucose and protein metabolism. J Cachexia Sarcopenia Muscle, 15(2), 603-614. Abstract. Author URL.
van der Heijden I, West S, Monteyne AJ, Finnigan TJA, Abdelrahman DR, Murton AJ, Stephens FB, Wall BT (2024). Ingestion of a variety of non-animal-derived dietary protein sources results in diverse postprandial plasma amino acid responses which differ between young and older adults. Br J Nutr, 1-14. Abstract. Author URL.
Pavis GF, Abdelrahman DR, Murton AJ, Wall BT, Stephens FB, Dirks ML (2024). Nasogastric bolus administration of a protein-rich drink augments insulinaemia and aminoacidaemia but not whole-body protein turnover or muscle protein synthesis versus oral administration. Clin Sci (Lond), 138(1), 43-60. Abstract. Author URL.
Wilhelmsen A, Stephens FB, Bennett AJ, Karagounis LG, Jones SW, Tsintzas K (2024). Skeletal muscle myostatin mRNA expression is upregulated in aged human adults with excess adiposity but is not associated with insulin resistance and ageing. Geroscience, 46(2), 2033-2049. Abstract. Author URL.
Dirks ML, Jameson TSO, Andrews RC, Dunlop MV, Abdelrahman DR, Murton AJ, Wall BT, Stephens FB (2024). The impact of forearm immobilization and acipimox administration on muscle amino acid metabolism and insulin sensitivity in healthy, young volunteers. Am J Physiol Endocrinol Metab, 326(3), E277-E289. Abstract. Author URL.
van der Heijden I, West S, Monteyne AJ, Finnigan TJA, Abdelrahman DR, Murton AJ, Stephens FB, Wall BT (2023). Algae Ingestion Increases Resting and Exercised Myofibrillar Protein Synthesis Rates to a Similar Extent as Mycoprotein in Young Adults. J Nutr, 153(12), 3406-3417. Abstract. Author URL.
van der Heijden I, Monteyne AJ, Stephens FB, Wall BT (2023). Alternative dietary protein sources to support healthy and active skeletal muscle aging. Nutr Rev, 81(2), 206-230. Abstract. Author URL.
Wilkinson K, Koscien CP, Monteyne AJ, Wall BT, Stephens FB (2023). Association of postprandial postexercise muscle protein synthesis rates with dietary leucine: a systematic review. Physiol Rep, 11(15). Abstract. Author URL.
Wall BT, Machin D, Dunlop MV, Stephens FB (2023). Caffeine ingestion stimulates plasma carnitine clearance in humans. Physiol Rep, 11(4). Abstract. Author URL.
Jameson TSO, Caldow MK, Stephens F, Denehy L, Lynch GS, Koopman R, Krajcova A, Urban T, Berney S, Duska F, et al (2023). Inflammation and altered metabolism impede efficacy of functional electrical stimulation in critically ill patients. Critical Care, 27(1). Abstract.
West S, Monteyne AJ, Whelehan G, van der Heijden I, Abdelrahman DR, Murton AJ, Finnigan TJA, Stephens FB, Wall BT (2023). Ingestion of mycoprotein, pea protein, and their blend support comparable postexercise myofibrillar protein synthesis rates in resistance-trained individuals. Am J Physiol Endocrinol Metab, 325(3), E267-E279. Abstract. Author URL.
Holsgrove‐West RK, Revuelta Iniesta R, Abdelrahman DR, Murton AJ, Wall BT, Stephens FB (2023). Maximal sustainable energy intake during transatlantic ocean rowing is insufficient for total energy expenditure and skeletal muscle mass maintenance. Experimental Physiology, 109(2), 227-239. Abstract.
West S, Monteyne AJ, Whelehan G, Abdelrahman DR, Murton AJ, Finnigan TJA, Blackwell JR, Stephens FB, Wall BT (2023). Mycoprotein ingestion within or without its wholefood matrix results in equivalent stimulation of myofibrillar protein synthesis rates in resting and exercised muscle of young men. Br J Nutr, 130(1), 20-32. Abstract. Author URL.
West S, Monteyne AJ, van der Heijden I, Stephens FB, Wall BT (2023). Nutritional Considerations for the Vegan Athlete. Adv Nutr, 14(4), 774-795. Abstract. Author URL.
Wall BT, Stephens FB (2023). Reply to LTE: Does caffeine truly raise muscle carnitine in humans?. Physiol Rep, 11(17). Author URL.
Pavis GF, Abdelrahman DR, Murton AJ, Wall BT, Stephens FB, Dirks ML (2023). Short-term disuse does not affect postabsorptive or postprandial muscle protein fractional breakdown rates. Journal of Cachexia, Sarcopenia and Muscle, 14(5), 2064-2075. Abstract.
Monteyne AJ, Coelho MOC, Murton AJ, Abdelrahman DR, Blackwell JR, Koscien CP, Knapp KM, Fulford J, Finnigan TJA, Dirks ML, et al (2023). Vegan and Omnivorous High Protein Diets Support Comparable Daily Myofibrillar Protein Synthesis Rates and Skeletal Muscle Hypertrophy in Young Adults. J Nutr, 153(6), 1680-1695. Abstract. Author URL.
Wilhelmsen A, Davies A, Mallinson J, Pabla P, Jones R, Palmer EA, Dunn WB, Moran GW, Stephens FB, Tsintzas K, et al (2022). Acute effects of prior dietary fat ingestion on postprandial metabolic responses to protein and carbohydrate co-ingestion in overweight and obese men: a randomised crossover trial. Clin Nutr, 41(8), 1623-1635. Abstract. Author URL.
Frankum R, Jameson TSO, Knight BA, Stephens FB, Wall BT, Donlon TA, Torigoe T, Willcox BJ, Willcox DC, Allsopp RC, et al (2022). Correction to: Extreme longevity variants at the FOXO3 locus may moderate FOXO3 isoform levels. Geroscience, 44(2), 1169-1170. Author URL.
Pavis GF, Jameson TSO, Blackwell JR, Fulford J, Abdelrahman DR, Murton AJ, Alamdari N, Mikus CR, Wall BT, Stephens FB, et al (2022). Daily protein-polyphenol ingestion increases daily myofibrillar protein synthesis rates and promotes early muscle functional gains during resistance training. Am J Physiol Endocrinol Metab, 322(3), E231-E249. Abstract. Author URL.
Pavis GF, Jameson TSO, Blackwell JR, Fulford J, Abdelrahman DR, Murton AJ, Alamdari N, Mikus CR, Wall BT, Stephens FB, et al (2022). Erratum: Corrigendum for Pavis et al.(American Journal of Physiology - Endocrinology and Metabolism (2022) 322 (E231–E249) DOI: 10.1152/ajpendo.00328.2021). American Journal of Physiology - Endocrinology and Metabolism, 323(1). Abstract.
Coelho MOC, Monteyne AJ, Kamalanathan ID, Najdanovic-Visak V, Finnigan TJA, Stephens FB, Wall BT (2022). High dietary nucleotide consumption for one week increases circulating uric acid concentrations but does not compromise metabolic health: a randomised controlled trial. Clinical Nutrition ESPEN, 49, 40-52. Abstract.
Shur NF, Simpson EJ, Crossland H, Chivaka PK, Constantin D, Cordon SM, Constantin-Teodosiu D, Stephens FB, Lobo DN, Szewczyk N, et al (2022). Human adaptation to immobilization: Novel insights of impacts on glucose disposal and fuel utilization. JOURNAL OF CACHEXIA SARCOPENIA AND MUSCLE, 13(6), 2999-3013. Author URL.
Jameson TSO, Islam H, Wall BT, Little JP, Stephens FB (2022). Oral ketone monoester supplementation does not accelerate recovery of muscle force or modulate circulating cytokine concentrations after muscle‐damaging eccentric exercise in healthy males and females. Experimental Physiology, 107(11), 1339-1348. Abstract.
Burley MJ, Blackwell J, Bond B, Williams C, Stephens FB (2022). The effect of various breath‐hold techniques on the cardiorespiratory response to facial immersion in humans. Experimental Physiology, 108(1), 50-62. Abstract.
Monteyne AJ, Dunlop MV, Machin DJ, Coelho MOC, Pavis GF, Porter C, Murton AJ, Abdelrahman DR, Dirks ML, Stephens FB, et al (2021). A mycoprotein-based high-protein vegan diet supports equivalent daily myofibrillar protein synthesis rates compared with an isonitrogenous omnivorous diet in older adults: a randomised controlled trial. Br J Nutr, 126(5), 674-684. Abstract. Author URL.
Coelho MOC, Monteyne AJ, Dirks ML, Finnigan TJA, Stephens FB, Wall BT (2021). Daily mycoprotein consumption for 1 week does not affect insulin sensitivity or glycaemic control but modulates the plasma lipidome in healthy adults: a randomised controlled trial. Br J Nutr, 125(2), 147-160. Abstract. Author URL.
Frankum R, Jameson TSO, Knight BA, Stephens FB, Wall BT, Donlon TA, Torigoe T, Willcox BJ, Willcox DC, Allsopp RC, et al (2021). Extreme longevity variants at the FOXO3 locus may moderate FOXO3 isoform levels. GeroScience, 44(2), 1129-1140. Abstract.
Burns AM, Nixon A, Mallinson J, Cordon SM, Stephens FB, Greenhaff PL (2021). Immobilisation induces sizeable and sustained reductions in forearm glucose uptake in just 24 h but does not change lipid uptake in healthy men. J Physiol, 599(8), 2197-2210. Abstract. Author URL.
Pavis GF, Jameson TSO, Dirks ML, Lee BP, Abdelrahman DR, Murton AJ, Porter C, Alamdari N, Mikus CR, Wall BT, et al (2021). Improved recovery from skeletal muscle damage is largely unexplained by myofibrillar protein synthesis or inflammatory and regenerative gene expression pathways. Am J Physiol Endocrinol Metab, 320(2), E291-E305. Abstract. Author URL.
Chee C, Shannon CE, Burns A, Selby AL, Wilkinson D, Smith K, Greenhaff PL, Stephens FB (2021). Increasing skeletal muscle carnitine content in older individuals increases whole-body fat oxidation during moderate-intensity exercise. Aging Cell, 20(2). Abstract. Author URL.
Jameson TSO, Kilroe SP, Fulford J, Abdelrahman DR, Murton AJ, Dirks ML, Stephens FB, Wall BT (2021). Muscle damaging eccentric exercise attenuates disuse-induced declines in daily myofibrillar protein synthesis and transiently prevents muscle atrophy in healthy men. Am J Physiol Endocrinol Metab, 321(5), E674-E688. Abstract. Author URL.
Jameson TSO, Pavis GF, Dirks ML, Lee BP, Abdelrahman DR, Murton AJ, Porter C, Alamdari N, Mikus CR, Wall BT, et al (2021). Reducing NF-κB Signaling Nutritionally is Associated with Expedited Recovery of Skeletal Muscle Function After Damage. The Journal of Clinical Endocrinology & Metabolism, 106(7), 2057-2076. Abstract.
Davies A, Nixon A, Tsintzas K, Stephens FB, Moran GW (2021). Skeletal muscle anabolic and insulin sensitivity responses to a mixed meal in adult patients with active Crohn's disease. Clinical Nutrition ESPEN, 41, 305-313. Abstract.
Davenport AD, Jameson TSO, Kilroe SP, Monteyne AJ, Pavis GF, Wall BT, Dirks ML, Alamdari N, Mikus CR, Stephens FB, et al (2020). A Randomised, Placebo-Controlled, Crossover Study Investigating the Optimal Timing of a Caffeine-Containing Supplement for Exercise Performance. Sports Med Open, 6(1). Abstract. Author URL.
Monteyne AJ, Coelho MOC, Porter C, Abdelrahman DR, Jameson TSO, Finnigan TJA, Stephens FB, Dirks ML, Wall BT (2020). Branched-Chain Amino Acid Fortification Does Not Restore Muscle Protein Synthesis Rates following Ingestion of Lower- Compared with Higher-Dose Mycoprotein. J Nutr, 150(11), 2931-2941. Abstract. Author URL.
Dirks ML, Wall BT, Stephens FB (2020). CrossTalk opposing view: Intramuscular lipid accumulation does not cause insulin resistance. JOURNAL OF PHYSIOLOGY-LONDON, 598(18), 3807-3810. Author URL.
Tsintzas K, Jones R, Pabla P, Mallinson J, Barrett DA, Kim D-H, Cooper S, Davies A, Taylor T, Chee C, et al (2020). Effect of acute and short-term dietary fat ingestion on postprandial skeletal muscle protein synthesis rates in middle-aged, overweight, and obese men. Am J Physiol Endocrinol Metab, 318(3), E417-E429. Abstract. Author URL.
Shur N, Simpson EJ, Chivaka P, Crossland H, Constantin D, Constantin-Teodosiu T, Stephens FB, Lobo DN, Prats C, MacDonald IA, et al (2020). Impaired insulin sensitivity and carbohydrate oxidation during bed rest in healthy participants. Clinical Nutrition ESPEN, 40, 434-435.
Monteyne AJ, Coelho MOC, Porter C, Abdelrahman DR, Jameson TSO, Jackman SR, Blackwell JR, Finnigan TJA, Stephens FB, Dirks ML, et al (2020). Mycoprotein ingestion stimulates protein synthesis rates to a greater extent than milk protein in rested and exercised skeletal muscle of healthy young men: a randomized controlled trial. Am J Clin Nutr, 112(2), 318-333. Abstract. Author URL.
Dirks ML, Wall BT, Stephens FB (2020). Rebuttal from Marlou L. Dirks, Benjamin T. Wall and Francis B. Stephens. JOURNAL OF PHYSIOLOGY-LONDON, 598(18), 3813-3814. Author URL.
Davies A, Nixon A, Muhammed R, Tsintzas K, Kirkham S, Stephens FB, Moran GW (2020). Reduced skeletal muscle protein balance in paediatric Crohn's disease. Clinical Nutrition, 39(4), 1250-1257. Abstract.
Coelho MOC, Monteyne AJ, Kamalanathan ID, Najdanovic-Visak V, Finnigan TJA, Stephens FB, Wall BT (2020). Short-communication: Ingestion of a nucleotide-rich mixed meal increases serum uric acid concentrations but does not affect postprandial blood glucose or serum insulin responses in young adults. Nutrients, 12(4). Abstract.
Wall BT, Cruz AM, Otten B, Dunlop MV, Fulford J, Porter C, Abdelrahman DR, Stephens FB, Dirks ML (2020). The Impact of Disuse and High-Fat Overfeeding on Forearm Muscle Amino Acid Metabolism in Humans. The Journal of Clinical Endocrinology & Metabolism, 105(7), e2547-e2562. Abstract.
Waldauf P, Gojda J, Urban T, Hrušková N, Blahutová B, Hejnová M, Jiroutková K, Fric M, Jánský P, Kukulová J, et al (2019). Functional electrical stimulation-assisted cycle ergometry in the critically ill: Protocol for a randomized controlled trial. Trials, 20(1). Abstract.
Dirks ML, Wall BT, Otten B, Cruz AM, Dunlop MV, Barker AR, Stephens FB (2019). High-fat Overfeeding Does Not Exacerbate Rapid Changes in Forearm Glucose and Fatty Acid Balance During Immobilization. The Journal of Clinical Endocrinology & Metabolism, 105(1), 276-289. Abstract.
Coelho M, Monteyne A, Dunlop M, Harris H, Morrison D, Stephens F, Wall B (2019). Mycoprotein as a possible alternative source of dietary protein to support muscle and metabolic health. Nutrition Reviews
Finnigan TJA, Wall BT, Wilde PJ, Stephens FB, Taylor SL, Freedman MR (2019). Mycoprotein: the Future of Nutritious Nonmeat Protein, a Symposium Review. Curr Dev Nutr, 3(6). Abstract. Author URL.
Dirks ML, Stephens FB, Jackman SR, Gordo J, Machin D, Pulsford R, van Loon L, Wall B (2018). A single day of bed rest, irrespective of energy balance, does not affect skeletal muscle gene expression or insulin sensitivity. Experimental Physiology, 103(6), 860-875.
Stephens FB (2018). Does skeletal muscle carnitine availability influence fuel selection during exercise?. Proceedings of the Nutrition Society, 77(1), 11-19. Abstract.
Parmar B, Lewis JE, Samms RJ, Ebling FJP, Cheng CC, Adams AC, Mallinson J, Cooper S, Taylor T, Ghasemi R, et al (2018). Eccentric exercise increases circulating fibroblast activation protein α but not bioactive fibroblast growth factor 21 in healthy humans. Exp Physiol, 103(6), 876-883. Abstract. Author URL.
Stephens FB, Tsintzas K (2018). Metabolic and molecular changes associated with the increased skeletal muscle insulin action 24-48 h after exercise in young and old humans. Biochem Soc Trans, 46(1), 111-118. Abstract. Author URL.
Walker A, Nixon A, Cordon S, Marshall M, Yeo M, Devadason D, Muhammed R, Tsintzas K, Kirkham S, Stephens F, et al (2018). P019 Paediatric Crohn’s disease patients in remission have a reduced skeletal muscle protein balance after feeding. Journal of Crohn's and Colitis, 12(supplement_1), s102-s103.
Murton AJ, Maddocks M, Stephens FB, Marimuthu K, England R, Wilcock A (2017). Consequences of Late-Stage Non-Small-Cell Lung Cancer Cachexia on Muscle Metabolic Processes. Clin Lung Cancer, 18(1), e1-e11. Abstract. Author URL.
Gaffney CJ, Mansell P, Stephens FB, Macdonald IA, Tsintzas K (2017). Exercise Metabolism in Nonobese Patients with Type 2 Diabetes Following the Acute Restoration of Normoglycaemia. J Diabetes Res, 2017 Abstract. Author URL.
Samms RJ, Lewis JE, Norton L, Stephens FB, Gaffney CJ, Butterfield T, Smith DP, Cheng CC, Perfield JW, Adams AC, et al (2017). FGF21 is an Insulin-Dependent Postprandial Hormone in Adult Humans. J Clin Endocrinol Metab, 102(10), 3806-3813. Abstract. Author URL.
Tsintzas K, Stephens FB, Snijders T, Wall BT, Cooper S, Mallinson J, Verdijk LB, van Loon LJC (2017). Intramyocellular lipid content and lipogenic gene expression responses following a single bout of resistance type exercise differ between young and older men. Exp Gerontol, 93, 36-45. Abstract. Author URL.
Shannon CE, Greenhaff PL, Stephens FB (2016). Increasing Skeletal Muscle Carnitine Availability During High Intensity Interval Training. The FASEB Journal, 30(S1).
Shannon CE, Nixon AV, Greenhaff PL, Stephens FB (2016). Protein ingestion acutely inhibits insulin-stimulated muscle carnitine uptake in healthy young men. American Journal of Clinical Nutrition, 103(1), 276-282. Abstract.
Chee C, Shannon CE, Burns A, Selby AL, Wilkinson D, Smith K, Greenhaff PL, Stephens FB (2016). Relative contribution of intramyocellular lipid to whole-body fat oxidation is reduced with age but subsarcolemmal lipid accumulation and insulin resistance are only associated with overweight individuals. Diabetes, 65(4), 840-850. Abstract.
Chee C, Mansell P, Stephens F, Cordon S, Kaviani M, Hoad C, Bawden S, Gowland P, Macdonald I (2016). The effects of hyperenergetic carbohydrate vs fat diets on liver fat content and insulin sensitivity in overweight healthy males. DIABETIC MEDICINE, 33, 29-29. Author URL.
Murton AJ, Stephens FB, Billeter R, Wall BT (2015). COMMENTARY RESPONSE TO VIEWPOINT: "WHAT IS THE RELATIONSHIP BETWEEN ACUTE MEASURES OF MUSCLE PROTEIN SYNTHESIS AND CHANGES IN MUSCLE MASS?". JOURNAL OF APPLIED PHYSIOLOGY, 118(4), 500-500. Author URL.
Atherton PJ, Phillips BE, Brook MS, Wilkinson DJ, Smith K, Etheridge TE, Miller BF, Hamilton KL, Burd NA, Beals JW, et al (2015). Commentaries on Viewpoint: What is the relationship between acute measure of muscle protein synthesis and changes in muscle mass?. J Appl Physiol (1985), 118(4), 498-503. Author URL.
Stephens FB, Chee C, Wall BT, Murton AJ, Shannon CE, van Loon LJC, Tsintzas K (2015). Lipid-induced insulin resistance is associated with an impaired skeletal muscle protein synthetic response to amino acid ingestion in healthy young men. Diabetes, 64(5), 1615-1620. Abstract. Author URL.
Constantin-Teodosiu D, Stephens FB, Greenhaff PL (2015). Perpetual muscle PDH activation in PDH kinase knockout mice protects against high-fat feeding-induced muscle insulin resistance. Proceedings of the National Academy of Sciences of the United States of America, 112(8).
Wall BT, Dirks ML, Snijders T, Stephens FB, Senden JMG, Verscheijden M-L, van Loon LJC (2015). Short-term muscle disuse atrophy is not associated with increased intramuscular lipid deposition or a decline in the maximal activity of key mitochondrial enzymes in young and older males. Exp Gerontol, 61, 76-83. Abstract. Author URL.
Murton A, Chee C, Wall B, van Loon L, Tsintzas K, Stephens F (2014). Acute lipid administration inhibits amino acid induced phosphorylation of translation repressor 4E-BP1 in human muscle in an apparent mTOR independent manner. FASEB JOURNAL, 28(1). Author URL.
Murton A, Chee C, Wall B, van Loon L, Tsintzas K, Stephens F (2014). Acute lipid administration inhibits amino acid induced phosphorylation of translation repressor 4E‐BP1 in human muscle in an apparent mTOR independent manner (LB813). The FASEB Journal, 28(S1).
Stephens FB, Mendis B, Shannon CE, Cooper S, Ortori CA, Barrett DA, Mansell P, Tsintzas K (2014). Fish oil omega-3 fatty acids partially prevent lipid-induced insulin resistance in human skeletal muscle without limiting acylcarnitine accumulation. Clinical Science, 127(5), 315-322. Abstract.
Stephens F, Chee C, Wall B, Murton A, van Loon L, Tsintzas K (2014). Lipid-induced insulin resistance is associated with impaired muscle protein synthetic response to amino acid ingestion in healthy young men. FASEB JOURNAL, 28(1). Author URL.
Stephens F, Chee C, Wall B, Murton A, van Loon L, Tsintzas K (2014). Lipid‐induced insulin resistance is associated with impaired muscle protein synthetic response to amino acid ingestion in healthy young men (1168.2). The FASEB Journal, 28(S1).
Shannon C, Nixon A, Greenhaff P, Stephens F (2014). Protein ingestion impairs insulin-stimulated net muscle carnitine uptake in healthy young men. FASEB JOURNAL, 28(1). Author URL.
Shannon C, Nixon A, Greenhaff P, Stephens F (2014). Protein ingestion impairs insulin‐stimulated net muscle carnitine uptake in healthy young men (LB812). The FASEB Journal, 28(S1).
Wall B, Dirks M, Snijders T, Stephens F, Senden J, van Loon L (2014). Short-term muscle disuse atrophy is not associated with increased skeletal muscle lipid accumulation or impaired oxidative enzyme activity in young or old men. FASEB JOURNAL, 28(1). Author URL.
Wall B, Dirks M, Snijders T, Stephens F, Senden J, van Loon L (2014). Short‐term muscle disuse atrophy is not associated with increased skeletal muscle lipid accumulation or impaired oxidative enzyme activity in young or old men (863.1). The FASEB Journal, 28(S1).
Murton AJ, Billeter R, Stephens FB, Des Etages SG, Graber F, Hill RJ, Marimuthu K, Greenhaff PL (2014). Transient transcriptional events in human skeletal muscle at the outset of concentric resistance exercise training. Journal of Applied Physiology, 116(1), 113-125. Abstract.
Gunnarsson TP, Bendiksen M, Bischoff R, Christensen PM, Lesivig B, Madsen K, Stephens F, Greenhaff P, Krustrup P, Bangsbo J, et al (2013). Effect of whey protein- and carbohydrate-enriched diet on glycogen resynthesis during the first 48 h after a soccer game. Scand J Med Sci Sports, 23(4), 508-515. Abstract. Author URL.
Gunnarsson TP, Bendiksen M, Bischoff R, Christensen PM, Lesivig B, Madsen K, Stephens F, Greenhaff P, Krustrup P, Bangsbo J, et al (2013). Effect of whey protein- and carbohydrate-enriched diet on glycogen resynthesis during the first 48h after a soccer game. Scandinavian Journal of Medicine and Science in Sports, 23(4), 508-515. Abstract.
Tsintzas K, Norton L, Chokkalingam K, Nizamani N, Cooper S, Stephens F, Billeter R, Bennett A (2013). Independent and combined effects of acute physiological hyperglycaemia and hyperinsulinaemia on metabolic gene expression in human skeletal muscle. Clinical Science, 124(11), 675-684. Abstract.
Stephens F (2013). REVISITING THE ERGOGENIC PROPERTIES OF L-CARNITINE. ANNALS OF NUTRITION AND METABOLISM, 63, 30-31. Author URL.
Wall BT, Stephens FB, van Loon LJC, Constantin-Teodosiu D, Macdonald IA, Greenhaff PL (2013). Reduced fat oxidation during high intensity, submaximal exercise: is the availability of carnitine important?. European Journal of Sport Science, 13(2), 191-199. Abstract.
Stephens FB, Wall BT, Marimuthu K, Shannon CE, Constantin-Teodosiu D, Macdonald IA, Greenhaff PL (2013). Skeletal muscle carnitine loading increases energy expenditure, modulates fuel metabolism gene networks and prevents body fat accumulation in humans. Journal of Physiology, 591(18), 4655-4666. Abstract.
Stephens FB, Wall BT, Marimuthu K, Shannon CE, Constantin-Teodosiu D, Macdonald IA, Greenhaff PL (2013). Skeletal muscle carnitine loading increases energy expenditure, modulates fuel metabolism gene networks and prevents body fat accumulation in humans. J Physiol, 591(18), 4655-4666. Abstract. Author URL.
Wall BT, Stephens FB, Marimuthu K, Constantin-Teodosiu D, Macdonald IA, Greenhaff PL (2012). Acute pantothenic acid and cysteine supplementation does not affect muscle coenzyme a content, fuel selection, or exercise performance in healthy humans. J Appl Physiol (1985), 112(2), 272-278. Abstract. Author URL.
Awad S, Stephens F, Shannon C, Lobo DN (2012). Perioperative perturbations in carnitine metabolism are attenuated by preoperative carbohydrate treatment: Another mechanism by which preoperative feeding may attenuate development of postoperative insulin resistance. Clinical Nutrition, 31(5), 717-720. Abstract.
Constantin-Teodosiu D, Constantin D, Stephens F, Laithwaite D, Greenhaff PL (2012). The role of FOXO and PPAR transcription factors in diet-mediated inhibition of PDC activation and carbohydrate oxidation during exercise in humans and the role of pharmacological activation of PDC in overriding these changes. Diabetes, 61(5), 1017-1024. Abstract.
Wall BT, Stephens FB, Constantin-Teodosiu D, Marimuthu K, Macdonald IA, Greenhaff PL (2011). Chronic oral ingestion of L-carnitine and carbohydrate increases muscle carnitine content and alters muscle fuel metabolism during exercise in humans. J Physiol, 589(Pt 4), 963-973. Abstract. Author URL.
Wall BT, Stephens FB, Constantin-Teodosiu D, Marimuthu K, Macdonald IA, Greenhaff PL (2011). Chronic oral ingestion of l-carnitine and carbohydrate increases muscle carnitine content and alters muscle fuel metabolism during exercise in humans. Journal of Physiology, 589(4), 963-973. Abstract.
Wall BT, Stephens FB, Constantin-Teodosiu D, Marimuthu K, Macdonald IA, Greenhaff PL (2011). Increasing muscle carnitine content alters muscle fuel metabolism and improves exercise performance in humans. JAPANESE JOURNAL OF PHYSICAL FITNESS AND SPORTS MEDICINE, 60(1), 85-85. Author URL.
Krustrup P, Ortenblad N, Nielsen J, Nybo L, Gunnarsson TP, Iaia FM, Madsen K, Stephens F, Greenhaff P, Bangsbo J, et al (2011). Maximal voluntary contraction force, SR function and glycogen resynthesis during the first 72 h after a high-level competitive soccer game. Eur J Appl Physiol, 111(12), 2987-2995. Abstract. Author URL.
Stephens FB, Marimuthu K, Cheng Y, Patel N, Constantin D, Simpson EJ, Greenhaff PL (2011). Vegetarians have a reduced skeletal muscle carnitine transport capacity. American Journal of Clinical Nutrition, 94(3), 938-944. Abstract.
Stephens FB, Norton L, Jewell K, Chokkalingam K, Parr T, Tsintzas K (2010). Basal and insulin-stimulated pyruvate dehydrogenase complex activation, glycogen synthesis and metabolic gene expression in human skeletal muscle the day after a single bout of exercise. Experimental Physiology, 95(7), 808-818. Abstract.
Stephens FB (2010). New developments in sports nutrition. Food Science and Technology, 24(2), 31-33. Abstract.
Burke LM, Castell LM, Stear SJ, Rogers PJ, Blomstrand E, Gurr S, Mitchell N, Stephens FB, Greenhaff PL (2009). BJSM reviews: A-Z of nutritional supplements: Dietary supplements, sports nutrition foods and ergogenic aids for health and performance Part 4. British Journal of Sports Medicine, 43(14), 1088-1090.
Stephens FB, Roig M, Armstrong G, Greenhaff PL (2008). Post-exercise ingestion of a unique, high molecular weight glucose polymer solution improves performance during a subsequent bout of cycling exercise. Journal of Sports Sciences, 26(2), 149-154. Abstract.
Stephens FB, Constantin-Teodosiu D, Greenhaff PL (2007). A central role for carnitine in the in vivo regulation of fuel metabolism in skeletal muscle. AMINO ACIDS, 33(3), LX-LX. Author URL.
Stephens FB, Constantin-Teodosiu D, Laithwaite D, Simpson EJ, Greenhaff PL (2007). A threshold exists for the stimulatory effect of insulin on plasma L-carnitine clearance in humans. American Journal of Physiology - Endocrinology and Metabolism, 292(2). Abstract.
Stephens FB, Evans CE, Constantin-Teodosiu D, Greenhaff PL (2007). Carbohydrate ingestion augments L-carnitine retention in humans. Journal of Applied Physiology, 102(3), 1065-1070. Abstract.
Stephens FB, Constantin-teodosiu D, Greenhaff PL (2007). New insights concerning the role of carnitine in the regulation of fuel metabolism in skeletal muscle. Journal of Physiology, 581(2), 431-444. Abstract.
Stephens FB, Constantin-Teodosiu D, Laithwaite D, Simpson EJ, Greenhaff PL (2006). An acute increase in skeletal muscle carnitine content alters fuel metabolism in resting human skeletal muscle. Journal of Clinical Endocrinology and Metabolism, 91(12), 5013-5018. Abstract.
Stephens FB, Constantin-Teodosiu D, Laithwaite D, Simpson EJ, Greenhaff PL (2006). Insulin stimulates L-carnitine accumulation in human skeletal muscle. FASEB Journal, 20(2), 377-379.
Chapters
Stephens F (2016). Skeletal muscle carnitine transport. In (Ed) Carnitine Metabolism and Human Nutrition, 51-62.
Stephens FB, Greenhaff PL (2015). L-carnitine. In (Ed) Nutritional Supplements in Sport, Exercise and Health: an A-Z Guide, 78-79.
Stephens FB, Greenhaff PL (2013). Creatine. In (Ed) Sports Nutrition, 301-312.
Stephens FB, Greenhaff PL (2009). Metabolic Limitations to Performance. In (Ed) Olympic Textbook of Science in Sport, Wiley, 324-339.
Conferences
Derbyshire EJ, Theobald H, Wall BT, Stephens F (2023). Food for our future: the nutritional science behind the sustainable fungal protein - Mycoprotein. A symposium review. Abstract.
Dirks ML, Jameson TSO, Domingos L, Andrews RC, Stephens FB (2023). The effect of dietary branched-chain amino acid restriction during forearm immobilisation on whole-body and muscle insulin sensitivity. Author URL.
Shur NF, Simpson EJ, Chivaka PK, Crossland H, Constantin D, Cordon SM, Constantin-Teodosiu D, Stephens FB, Lobo DN, Szewczyk N, et al (2022). O105 Human adaptation to immobilisation: novel insights of impacts on glucose disposal and fuel utilization. Author URL.
Whelehan G, West S, Finnigan TJA, Wall BT, Stephens FB (2021). Mycoprotein reduces endogenous glucose production when consumed with a mixed-meal tolerance test. Author URL.
Jameson TSO, Pavis GF, Dirks ML, Wall BT, Mikus C, Alamdari N, Stephens FB (2019). Post-exercise and Pre-sleep Protein-polyphenol Supplementation Improves Recovery Following Muscle-damaging Eccentric Exercise: Preliminary Findings. Author URL.
Moran G, Walker A, Nixon A, Devadason D, Muhammed R, Tsintzas K, Kirkham S, Stephens F (2018). PAEDIATRIC CROHN'S DISEASE PATIENTS IN REMISSION HAVE a REDUCED SKELETAL MUSCLE PROTEIN BALANCE AFTER FEEDING. Author URL.
Walker A, Nixon A, Cordon S, Marshall M, Yeo M, Devadason D, Muhammed R, Tsintzas K, Kirkham S, Stephens F, et al (2018). Paediatric Crohn's disease patients in remission have a reduced skeletal muscle protein balance after feeding. Author URL.
Coelho M, Monteyne AJ, Dirks ML, Finnigan TJA, Stephens FB, Wall BT (2018). Substituting meat/fish for mycoprotein for one week does not affect indices of metabolic health irrespective of dietary nucleotide load or serum uric acid concentrations in healthy young adults. Author URL.
Stephens FB, Gaffney CJ, Mansell P, Greenhaff PL, Tsintzas K (2017). Dietary fat oxidation is elevated in middle-aged type 2 diabetes. Author URL.
Burns A, Nixon A, Stephens F, Francis S, Gowland P, Greenhaff P (2016). Novel Insight Regarding the Trajectory and Time-course of Immobilisation Induced Impairment of Limb Glucose Uptake in Healthy Volunteers. Author URL.
Chee C, Mansell P, Stephens F, Cordon S, Kavani M, Bawden S, Hoad C, Gowland P, Macdonald I (2015). Differential effects of carbohydrate vs fat overfeeding on liver fat content and lipid metabolism in healthy overweight males. Author URL.
Stephens FB, Galloway SDR (2013). Carnitine and fat oxidation. Abstract.
Awad S, Stephens F, Shannon C, Lobo DN (2012). Carnitine, pre-operative carbohydrate loading and post-operative insulin resistance: a potential mechanism. Author URL.
Stephens F, Wall B, Constantin-Teodosiu D, Marimuthu K, Macdonald I, Greenhaff P (2011). Elevating skeletal muscle total carnitine content increases the expression of genes regulating fat metabolism in humans. Author URL.
Murton AJ, Billeter-Clark R, Stephens F, Marimuthu K, Greenhaff P (2011). The magnitude of exercise-induced change in the muscle transcriptome is related to the scale of muscle damage in humans. Author URL.
Stephens F, Constantin-Teodosiu T, Greenhaff P (2004). Insulin stimulates L-carnitine retention in humans. Author URL.
Francis_Stephens Details from cache as at 2024-04-18 05:10:44
Teaching
Modules
2023/24
- ESS3707 - Physiological Determinants of Exercise Performance
- SHSM022 - Physical Activity in the Prevention and Treatment of Chronic Disease