Dr Marlou Dirks
Postdoctoral Research Fellow

Key publications | Publications by category | Publications by year

Key publications



Dirks ML, Backx EMP, Wall BT, Verdijk LB, van Loon LJC (In Press). May bed rest cause greater muscle loss than limb immobilization?. Acta Physiol (Oxf), 218(1), 10-12. Author URL. DOI.
Dirks ML, Wall BT, Kramer IF, Zorenc AH, Goessens JPB, Gijsen AP, van Loon LJC (2016). A single session of neuromuscular electrical stimulation does not augment postprandial muscle protein accretion. Am J Physiol Endocrinol Metab, 311(1), E278-E285. Abstract.  Author URL.  Full text. DOI.
Wall BT, Dirks ML, Snijders T, van Dijk J-W, Fritsch M, Verdijk LB, van Loon LJC (2016). Short-term muscle disuse lowers myofibrillar protein synthesis rates and induces anabolic resistance to protein ingestion. Am J Physiol Endocrinol Metab, 310(2), E137-E147. Abstract.  Author URL.  Full text. DOI.
Dirks ML, Hansen D, Van Assche A, Dendale P, Van Loon LJC (2015). Neuromuscular electrical stimulation prevents muscle wasting in critically ill comatose patients. Clin Sci (Lond), 128(6), 357-365. Abstract.  Author URL. DOI.
Dirks ML, Wall BT, Snijders T, Ottenbros CLP, Verdijk LB, van Loon LJC (2014). Neuromuscular electrical stimulation prevents muscle disuse atrophy during leg immobilization in humans. Acta Physiol (Oxf), 210(3), 628-641. Abstract.  Author URL. DOI.
Dirks ML, Wall BT, Nilwik R, Weerts DHJM, Verdijk LB, van Loon LJC (2014). Skeletal muscle disuse atrophy is not attenuated by dietary protein supplementation in healthy older men. J Nutr, 144(8), 1196-1203. Abstract.  Author URL. DOI.

Publications by category


Journal articles

Dirks ML, Backx EMP, Wall BT, Verdijk LB, van Loon LJC (In Press). May bed rest cause greater muscle loss than limb immobilization?. Acta Physiol (Oxf), 218(1), 10-12. Author URL. DOI.
Dirks ML, Wall BT, van de Valk B, Holloway TM, Holloway GP, Chabowski A, Goossens GH, van Loon LJC (In Press). One Week of Bed Rest Leads to Substantial Muscle Atrophy and Induces Whole-Body Insulin Resistance in the Absence of Skeletal Muscle Lipid Accumulation. Diabetes, 65(10), 2862-2875. Abstract.  Author URL.  Full text. DOI.
Dirks ML, Stephens FB, Jackman SR, Gordo J, Machin D, Pulsford R, van Loon L, Wall B (2018). A single day of bed rest, irrespective of energy balance, does not affect skeletal muscle gene expression or insulin sensitivity. Experimental Physiology Full text.
Holloway GP, Holwerda AM, Miotto PM, Dirks ML, Verdijk LB, van Loon LJC (2018). Age-Associated Impairments in Mitochondrial ADP Sensitivity Contribute to Redox Stress in Senescent Human Skeletal Muscle. Cell Rep, 22(11), 2837-2848. Abstract.  Author URL.  Full text. DOI.
Dirks ML, Wall BT, van Loon LJC (2017). Interventional strategies to combat muscle disuse atrophy in humans: focus on neuromuscular electrical stimulation and dietary protein. J Appl Physiol (1985) Abstract.  Author URL.  Full text. DOI.
Dirks ML, Groen BBL, Franssen R, van Kranenburg J, van Loon LJC (2017). Neuromuscular electrical stimulation prior to presleep protein feeding stimulates the use of protein-derived amino acids for overnight muscle protein synthesis. J Appl Physiol (1985), 122(1), 20-27. Abstract.  Author URL.  Full text. DOI.
Dirks ML, Tieland M, Verdijk LB, Losen M, Nilwik R, Mensink M, de Groot LCPGM, van Loon LJC (2017). Protein Supplementation Augments Muscle Fiber Hypertrophy but Does Not Modulate Satellite Cell Content During Prolonged Resistance-Type Exercise Training in Frail Elderly. Journal of the American Medical Directors Association, 18(7), 608-615. Abstract.  Full text. DOI.
Dirks ML, Wall BT, Kramer IF, Zorenc AH, Goessens JPB, Gijsen AP, van Loon LJC (2016). A single session of neuromuscular electrical stimulation does not augment postprandial muscle protein accretion. Am J Physiol Endocrinol Metab, 311(1), E278-E285. Abstract.  Author URL.  Full text. DOI.
Wall BT, Dirks ML, Snijders T, van Dijk J-W, Fritsch M, Verdijk LB, van Loon LJC (2016). Short-term muscle disuse lowers myofibrillar protein synthesis rates and induces anabolic resistance to protein ingestion. Am J Physiol Endocrinol Metab, 310(2), E137-E147. Abstract.  Author URL.  Full text. DOI.
Ninivaggi M, de Laat M, Lancé MMD, Kicken CH, Pelkmans L, Bloemen S, Dirks ML, van Loon LJC, Govers-Riemslag JWP, Lindhout T, et al (2015). Hypoxia Induces a Prothrombotic State Independently of the Physical Activity. PLoS One, 10(10). Abstract.  Author URL. DOI.
Dirks ML, Hansen D, Van Assche A, Dendale P, Van Loon LJC (2015). Neuromuscular electrical stimulation prevents muscle wasting in critically ill comatose patients. Clin Sci (Lond), 128(6), 357-365. Abstract.  Author URL. DOI.
Wall BT, Dirks ML, Snijders T, Stephens FB, Senden JMG, Verscheijden M-L, van Loon LJC (2015). Short-term muscle disuse atrophy is not associated with increased intramuscular lipid deposition or a decline in the maximal activity of key mitochondrial enzymes in young and older males. Exp Gerontol, 61, 76-83. Abstract.  Author URL.  Full text. DOI.
Churchward-Venne TA, Tieland M, Verdijk LB, Leenders M, Dirks ML, de Groot LCPGM, van Loon LJC (2015). There Are No Nonresponders to Resistance-Type Exercise Training in Older Men and Women. J Am Med Dir Assoc, 16(5), 400-411. Abstract.  Author URL. DOI.
Snijders T, Wall BT, Dirks ML, Senden JMG, Hartgens F, Dolmans J, Losen M, Verdijk LB, van Loon LJC (2014). Muscle disuse atrophy is not accompanied by changes in skeletal muscle satellite cell content. Clin Sci (Lond), 126(8), 557-566. Abstract.  Author URL. DOI.
Dirks ML, Wall BT, Snijders T, Ottenbros CLP, Verdijk LB, van Loon LJC (2014). Neuromuscular electrical stimulation prevents muscle disuse atrophy during leg immobilization in humans. Acta Physiol (Oxf), 210(3), 628-641. Abstract.  Author URL. DOI.
Dirks ML, Wall BT, Nilwik R, Weerts DHJM, Verdijk LB, van Loon LJC (2014). Skeletal muscle disuse atrophy is not attenuated by dietary protein supplementation in healthy older men. J Nutr, 144(8), 1196-1203. Abstract.  Author URL. DOI.
Wall BT, Dirks ML, Snijders T, Senden JMG, Dolmans J, van Loon LJC (2014). Substantial skeletal muscle loss occurs during only 5 days of disuse. Acta Physiol (Oxf), 210(3), 600-611. Abstract.  Author URL. DOI.
Wall BT, Dirks ML, van Loon LJC (2013). Skeletal muscle atrophy during short-term disuse: implications for age-related sarcopenia. Ageing Res Rev, 12(4), 898-906. Abstract.  Author URL. DOI.
Jonkers RAM, Dirks ML, Nabuurs CIHC, De Feyter HM, Praet SFE, Nicolay K, van Loon LJC, Prompers JJ (2012). Myofibrillar distribution of succinate dehydrogenase activity and lipid stores differs in skeletal muscle tissue of paraplegic subjects. AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM, 302(3), E365-E373. Author URL. DOI.
Wall BT, Dirks ML, Verdijk LB, Snijders T, Hansen D, Vranckx P, Burd NA, Dendale P, van Loon LJC (2012). Neuromuscular electrical stimulation increases muscle protein synthesis in elderly type 2 diabetic men. Am J Physiol Endocrinol Metab, 303(5), E614-E623. Abstract.  Author URL. DOI.
Tieland M, van de Rest O, Dirks ML, van der Zwaluw N, Mensink M, van Loon LJC, de Groot LCPGM (2012). Protein Supplementation Improves Physical Performance in Frail Elderly People: a Randomized, Double-Blind, Placebo-Controlled Trial. JOURNAL OF THE AMERICAN MEDICAL DIRECTORS ASSOCIATION, 13(8), 720-726. Author URL. DOI.
Tieland M, Dirks ML, van der Zwaluw N, Verdijk LB, van de Rest O, de Groot LCPGM, van Loon LJC (2012). Protein Supplementation Increases Muscle Mass Gain During Prolonged Resistance-Type Exercise Training in Frail Elderly People: a Randomized, Double-Blind, Placebo-Controlled Trial. JOURNAL OF THE AMERICAN MEDICAL DIRECTORS ASSOCIATION, 13(8), 713-719. Author URL. DOI.
Verdijk LB, Dirks ML, Snijders T, Prompers JJ, Beelen M, Jonkers RAM, Thijssen DHJ, Hopman MTE, Van Loon LJC (2012). Reduced satellite cell numbers with spinal cord injury and aging in humans. Med Sci Sports Exerc, 44(12), 2322-2330. Abstract.  Author URL. DOI.

Conferences

Dirks M, Wall B, Goossens G, van de Valk B, van Loon L (2015). One Week of Bed-rest Substantially Reduces Muscle Mass and Induces Insulin Resistance in Healthy, Young Males.  Author URL.
Dirks ML, Hansen D, Vranckx P, Van Assche A, Dendale P, van Loon LJC (2014). Neuromuscular Electrical Stimulation Prevents Skeletal Muscle Fiber Atrophy in Fully Sedated ICU Patients.  Author URL. DOI.
Wall BT, Dirks ML, Snijders T, Verdijk LB, Kuipers H, van Loon LJC (2013). Substantial Muscle Loss Occurs in the First 5 Days of Muscle Disuse in Humans.  Author URL.

Publications by year



In Press

Dirks ML, Backx EMP, Wall BT, Verdijk LB, van Loon LJC (In Press). May bed rest cause greater muscle loss than limb immobilization?. Acta Physiol (Oxf), 218(1), 10-12. Author URL. DOI.
Dirks ML, Wall BT, van de Valk B, Holloway TM, Holloway GP, Chabowski A, Goossens GH, van Loon LJC (In Press). One Week of Bed Rest Leads to Substantial Muscle Atrophy and Induces Whole-Body Insulin Resistance in the Absence of Skeletal Muscle Lipid Accumulation. Diabetes, 65(10), 2862-2875. Abstract.  Author URL.  Full text. DOI.

2018

Dirks ML, Stephens FB, Jackman SR, Gordo J, Machin D, Pulsford R, van Loon L, Wall B (2018). A single day of bed rest, irrespective of energy balance, does not affect skeletal muscle gene expression or insulin sensitivity. Experimental Physiology Full text.
Holloway GP, Holwerda AM, Miotto PM, Dirks ML, Verdijk LB, van Loon LJC (2018). Age-Associated Impairments in Mitochondrial ADP Sensitivity Contribute to Redox Stress in Senescent Human Skeletal Muscle. Cell Rep, 22(11), 2837-2848. Abstract.  Author URL.  Full text. DOI.

2017

Dirks ML, Wall BT, van Loon LJC (2017). Interventional strategies to combat muscle disuse atrophy in humans: focus on neuromuscular electrical stimulation and dietary protein. J Appl Physiol (1985) Abstract.  Author URL.  Full text. DOI.
Dirks ML, Groen BBL, Franssen R, van Kranenburg J, van Loon LJC (2017). Neuromuscular electrical stimulation prior to presleep protein feeding stimulates the use of protein-derived amino acids for overnight muscle protein synthesis. J Appl Physiol (1985), 122(1), 20-27. Abstract.  Author URL.  Full text. DOI.
Dirks ML, Tieland M, Verdijk LB, Losen M, Nilwik R, Mensink M, de Groot LCPGM, van Loon LJC (2017). Protein Supplementation Augments Muscle Fiber Hypertrophy but Does Not Modulate Satellite Cell Content During Prolonged Resistance-Type Exercise Training in Frail Elderly. Journal of the American Medical Directors Association, 18(7), 608-615. Abstract.  Full text. DOI.

2016

Dirks ML, Wall BT, Kramer IF, Zorenc AH, Goessens JPB, Gijsen AP, van Loon LJC (2016). A single session of neuromuscular electrical stimulation does not augment postprandial muscle protein accretion. Am J Physiol Endocrinol Metab, 311(1), E278-E285. Abstract.  Author URL.  Full text. DOI.
Wall BT, Dirks ML, Snijders T, van Dijk J-W, Fritsch M, Verdijk LB, van Loon LJC (2016). Short-term muscle disuse lowers myofibrillar protein synthesis rates and induces anabolic resistance to protein ingestion. Am J Physiol Endocrinol Metab, 310(2), E137-E147. Abstract.  Author URL.  Full text. DOI.

2015

Ninivaggi M, de Laat M, Lancé MMD, Kicken CH, Pelkmans L, Bloemen S, Dirks ML, van Loon LJC, Govers-Riemslag JWP, Lindhout T, et al (2015). Hypoxia Induces a Prothrombotic State Independently of the Physical Activity. PLoS One, 10(10). Abstract.  Author URL. DOI.
Dirks ML, Hansen D, Van Assche A, Dendale P, Van Loon LJC (2015). Neuromuscular electrical stimulation prevents muscle wasting in critically ill comatose patients. Clin Sci (Lond), 128(6), 357-365. Abstract.  Author URL. DOI.
Dirks M, Wall B, Goossens G, van de Valk B, van Loon L (2015). One Week of Bed-rest Substantially Reduces Muscle Mass and Induces Insulin Resistance in Healthy, Young Males.  Author URL.
Wall BT, Dirks ML, Snijders T, Stephens FB, Senden JMG, Verscheijden M-L, van Loon LJC (2015). Short-term muscle disuse atrophy is not associated with increased intramuscular lipid deposition or a decline in the maximal activity of key mitochondrial enzymes in young and older males. Exp Gerontol, 61, 76-83. Abstract.  Author URL.  Full text. DOI.
Churchward-Venne TA, Tieland M, Verdijk LB, Leenders M, Dirks ML, de Groot LCPGM, van Loon LJC (2015). There Are No Nonresponders to Resistance-Type Exercise Training in Older Men and Women. J Am Med Dir Assoc, 16(5), 400-411. Abstract.  Author URL. DOI.

2014

Snijders T, Wall BT, Dirks ML, Senden JMG, Hartgens F, Dolmans J, Losen M, Verdijk LB, van Loon LJC (2014). Muscle disuse atrophy is not accompanied by changes in skeletal muscle satellite cell content. Clin Sci (Lond), 126(8), 557-566. Abstract.  Author URL. DOI.
Dirks ML, Hansen D, Vranckx P, Van Assche A, Dendale P, van Loon LJC (2014). Neuromuscular Electrical Stimulation Prevents Skeletal Muscle Fiber Atrophy in Fully Sedated ICU Patients.  Author URL. DOI.
Dirks ML, Wall BT, Snijders T, Ottenbros CLP, Verdijk LB, van Loon LJC (2014). Neuromuscular electrical stimulation prevents muscle disuse atrophy during leg immobilization in humans. Acta Physiol (Oxf), 210(3), 628-641. Abstract.  Author URL. DOI.
Dirks ML, Wall BT, Nilwik R, Weerts DHJM, Verdijk LB, van Loon LJC (2014). Skeletal muscle disuse atrophy is not attenuated by dietary protein supplementation in healthy older men. J Nutr, 144(8), 1196-1203. Abstract.  Author URL. DOI.
Wall BT, Dirks ML, Snijders T, Senden JMG, Dolmans J, van Loon LJC (2014). Substantial skeletal muscle loss occurs during only 5 days of disuse. Acta Physiol (Oxf), 210(3), 600-611. Abstract.  Author URL. DOI.

2013

Wall BT, Dirks ML, van Loon LJC (2013). Skeletal muscle atrophy during short-term disuse: implications for age-related sarcopenia. Ageing Res Rev, 12(4), 898-906. Abstract.  Author URL. DOI.
Wall BT, Dirks ML, Snijders T, Verdijk LB, Kuipers H, van Loon LJC (2013). Substantial Muscle Loss Occurs in the First 5 Days of Muscle Disuse in Humans.  Author URL.

2012

Jonkers RAM, Dirks ML, Nabuurs CIHC, De Feyter HM, Praet SFE, Nicolay K, van Loon LJC, Prompers JJ (2012). Myofibrillar distribution of succinate dehydrogenase activity and lipid stores differs in skeletal muscle tissue of paraplegic subjects. AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM, 302(3), E365-E373. Author URL. DOI.
Wall BT, Dirks ML, Verdijk LB, Snijders T, Hansen D, Vranckx P, Burd NA, Dendale P, van Loon LJC (2012). Neuromuscular electrical stimulation increases muscle protein synthesis in elderly type 2 diabetic men. Am J Physiol Endocrinol Metab, 303(5), E614-E623. Abstract.  Author URL. DOI.
Tieland M, van de Rest O, Dirks ML, van der Zwaluw N, Mensink M, van Loon LJC, de Groot LCPGM (2012). Protein Supplementation Improves Physical Performance in Frail Elderly People: a Randomized, Double-Blind, Placebo-Controlled Trial. JOURNAL OF THE AMERICAN MEDICAL DIRECTORS ASSOCIATION, 13(8), 720-726. Author URL. DOI.
Tieland M, Dirks ML, van der Zwaluw N, Verdijk LB, van de Rest O, de Groot LCPGM, van Loon LJC (2012). Protein Supplementation Increases Muscle Mass Gain During Prolonged Resistance-Type Exercise Training in Frail Elderly People: a Randomized, Double-Blind, Placebo-Controlled Trial. JOURNAL OF THE AMERICAN MEDICAL DIRECTORS ASSOCIATION, 13(8), 713-719. Author URL. DOI.
Verdijk LB, Dirks ML, Snijders T, Prompers JJ, Beelen M, Jonkers RAM, Thijssen DHJ, Hopman MTE, Van Loon LJC (2012). Reduced satellite cell numbers with spinal cord injury and aging in humans. Med Sci Sports Exerc, 44(12), 2322-2330. Abstract.  Author URL. DOI.