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Dr Colleen Deane

Dr Colleen Deane

MRC Skills Development Fellow

 2882

 Haighton 

 

University of Exeter, St Luke's Campus, Exeter, EX1 2LU, UK

Overview

Colleen is a Medical Research Council Skills Development Fellow, utilising a multi-omics approach to understand the mechanisms underlying age-related muscle atrophy and hypertrophy. During this fellowship, Colleen is developing her computational modelling skills to complement her strong training background in skeletal muscle metabolic/molecular phsiology. 

Prior to being awarded her fellowship, Colleen was working as a post-doctoral research fellow under the supervision of Dr. Timothy Etheridge. During this time, Colleen worked on two main projects that were; i) investigaing whether NAD+ supplementation improved skeletal muscle mitochondrial function and physical capacity in older adults and, ii) establishing molecular mechanisms of and countermeasures to muscle decline in space. 

Colleen completed her Ph.D. in 2017, which investigated the metabolic and molecular mechanisms regulating age-related declines in human skeletal muscle regenerative capacity. Prior to her Ph.D., Colleen completed an MSc in Physical Activity, Nutrition and Health Promotion and a BSc in Sport and Exercise Science. 

 

 

Qualifications

Ph.D., MSc, BSc.

Career

Ph.D. Exploring Metabolic and Molecular Mechanisms Regulating Age-Related Declines in Human Skeletal Muscle Regenerative Capacity

MSc Physical Activity, Nutrition and Health Promotion 

BSc Sport and Exercise Science 

Research

Research interests

Skeletal muscle remodelling in the context of ageing, exercise, disuse and nutrition. 

Research projects

I am currently an Medical Research Council Skills Development Fellow, utilising a multi-omics approach to understand the mechanisms underlying age-related muscle atrophy and hypertrophy. 

Publications

Key publications | Publications by category | Publications by year

Publications by category


Journal articles

Hewitt JE, Pollard AK, Lesanpezeshki L, Deane CS, Gaffney CJ, Etheridge T, Szewczyk NJ, Vanapalli SA (In Press). Muscle strength deficiency and mitochondrial dysfunction in a muscular dystrophy model of C. elegans and its functional response to drugs. Disease Models & Mechanisms
Laranjeiro R, Harinath G, Pollard AK, Gaffney CJ, Deane CS, Vanapalli SA, Etheridge T, Szewczyk NJ, Driscoll M (In Press). Spaceflight Affects Neuronal Morphology and Alters Transcellular Degradation of Neuronal Debris in Adult Caenorhabditis elegans.  Abstract.
Sian TS, Din USU, Deane CS, Smith K, Gates A, Lund JN, Williams JP, Rueda R, Pereira SL, Phillips BE, et al (2021). Cocoa flavanols adjuvant to an oral nutritional supplement acutely enhances nutritive flow in skeletal muscle without altering leg glucose uptake kinetics in older adults. Nutrients, 13(5). Abstract.
Deane CS, Ely IA, Wilkinson DJ, Smith K, Phillips BE, Atherton PJ (2021). Dietary protein, exercise, ageing and physical inactivity: interactive influences on skeletal muscle proteostasis. Proc Nutr Soc, 80(2), 106-117. Abstract.  Author URL.
Maunder E, Bradley HE, Deane CS, Hodgson AB, Jones M, Joanisse S, Turner AM, Breen L, Philp A, Wallis GA, et al (2021). Effects of short-term graded dietary carbohydrate intake on intramuscular and whole body metabolism during moderate-intensity exercise. J Appl Physiol (1985), 131(1), 376-387. Abstract.  Author URL.
Deane CS, Gates A, Traviss-Turner GD, Wilkinson DJ, Smith K, Atherton PJ, Phillips BE (2021). Exploring the impact of COVID-19 on the willingness of older adults to participate in physiology research: views from past and potential volunteers. Applied Physiology, Nutrition, and Metabolism, 46(9), 1147-1151. Abstract.
Din USU, Sian TS, Deane CS, Smith K, Gates A, Lund JN, Williams JP, Rueda R, Pereira SL, Atherton PJ, et al (2021). Green Tea Extract Concurrent with an Oral Nutritional Supplement Acutely Enhances Muscle Microvascular Blood Flow without Altering Leg Glucose Uptake in Healthy Older Adults. Nutrients, 13(11), 3895-3895. Abstract.
Ellwood RA, Hewitt JE, Torregrossa R, Philp AM, Hardee JP, Hughes S, van de Klashorst D, Gharahdaghi N, Anupom T, Slade L, et al (2021). Mitochondrial hydrogen sulfide supplementation improves health in the C. elegans Duchenne muscular dystrophy model. Proceedings of the National Academy of Sciences, 118(9), e2018342118-e2018342118. Abstract.
Willis CRG, Deane CS (2021). Nrf2 deficiency induces skeletal muscle mitochondrial dysfunction: a proteomics/bioinformatics approach. J Physiol, 599(3), 729-730. Author URL.
Laranjeiro R, Harinath G, Pollard AK, Gaffney CJ, Deane CS, Vanapalli SA, Etheridge T, Szewczyk NJ, Driscoll M (2021). Spaceflight affects neuronal morphology and alters transcellular degradation of neuronal debris in adult Caenorhabditis elegans. iScience, 24(2). Abstract.
Bass JJ, Kazi AA, Deane CS, Nakhuda A, Ashcroft SP, Brook MS, Wilkinson DJ, Phillips BE, Philp A, Tarum J, et al (2021). The mechanisms of skeletal muscle atrophy in response to transient knockdown of the vitamin D receptor in vivo. J Physiol, 599(3), 963-979. Abstract.  Author URL.
Deane CS, Willis CRG, Phillips BE, Atherton PJ, Harries LW, Ames RM, Szewczyk NJ, Etheridge T (2021). Transcriptomic meta-analysis of disuse muscle atrophy vs. resistance exercise-induced hypertrophy in young and older humans. J Cachexia Sarcopenia Muscle, 12(3), 629-645. Abstract.  Author URL.
Deane C, Bass J, Crossland H, Phillips B, Atherton P (2020). Animal, Plant, Collagen and Blended Dietary Proteins: Effects on Musculoskeletal Outcomes. Nutrients, 12(9), 2670-2670. Abstract.
Deane CS, Phillips BE, Smith K, Steele AM, Libretto T, Statton SA, Atherton PJ, Etheridge T (2020). Challenges and practical recommendations for successfully recruiting inactive, statin-free older adults to clinical trials. BMC Research Notes, 13(1). Abstract.
Pollard AK, Gaffney CJ, Deane CS, Balsamo M, Cooke M, Ellwood RA, Hewitt JE, Mierzwa BE, Mariani A, Vanapalli SA, et al (2020). Molecular Muscle Experiment: Hardware and Operational Lessons for Future Astrobiology Space Experiments. Astrobiology, 20(8), 935-943. Abstract.  Author URL.
Willis CRG, Ames RM, Deane CS, Phillips BE, Boereboom CL, Abdulla H, Bukhari SSI, Lund JN, Williams JP, Wilkinson DJ, et al (2020). Network analysis of human muscle adaptation to aging and contraction. Aging (Albany NY), 12(1), 740-755. Abstract.  Author URL.
Bass JJ, Nakhuda A, Deane CS, Brook MS, Wilkinson DJ, Phillips BE, Philp A, Tarum J, Kadi F, Andersen D, et al (2020). Overexpression of the vitamin D receptor (VDR) induces skeletal muscle hypertrophy. Mol Metab, 42 Abstract.  Author URL.
Madrigal P, Gabel A, Villacampa A, Manzano A, Deane CS, Bezdan D, Carnero-Diaz E, Medina FJ, Hardiman G, Grosse I, et al (2020). Revamping Space-omics in Europe. Cell Systems, 11(6), 555-556.
Deane C, Szewczyk N (2019). Extraterrestrial life science. Biologist, 66(4), 12-15.
Deane CS, Ames RM, Phillips BE, Weedon MN, Willis CRG, Boereboom C, Abdulla H, Bukhari SSI, Lund JN, Williams JP, et al (2019). The acute transcriptional response to resistance exercise: impact of age and contraction mode. Aging (Albany NY), 11(7), 2111-2126. Abstract.  Author URL.
Dugdale HF, Hughes DC, Allan R, Deane CS, Coxon CR, Morton JP, Stewart CE, Sharples AP (2018). The role of resveratrol on skeletal muscle cell differentiation and myotube hypertrophy during glucose restriction. Molecular and Cellular Biochemistry, 444(1-2), 109-123. Abstract.
Gaffney CJ, Pollard AK, Deane CS, Cooke M, Balsamo M, Hewitt J, Vanapalli SA, Szewczyk NJ, Etheridge T, Phillips BE, et al (2018). Worms in Space for Outreach on Earth: Space Life Science Activities for the Classroom. Gravitational and Space Research, 6(2), 74-82.
Deane C, Pollard A, Cegielski J, Bass J (2018). YLS 2017: planning your first symposium – a pilot study. Physiology News(Winter 2017), 16-17.
Deane CS, Wilkinson DJ, Phillips BE, Smith K, Etheridge T, Atherton PJ (2017). "Nutraceuticals" in relation to human skeletal muscle and exercise. Am J Physiol Endocrinol Metab, 312(4), E282-E299. Abstract.  Author URL.
Sharples AP, Hughes DC, Deane CS, Saini A, Selman C, Stewart CE (2015). Longevity and skeletal muscle mass: the role of IGF signalling, the sirtuins, dietary restriction and protein intake. Aging Cell, 14(4), 511-523.
Deane C (2013). Book Review: Sporting Times (Palgrave Pivot). Sociological Research Online, 18(3), 188-189.
Deane C (2013). Book Review: Sporting Times (Palgrave Pivot). Sociological Research Online, 18(1), 248-249.
Deane CS, Hughes DC, Sculthorpe N, Lewis MP, Stewart CE, Sharples AP (2013). Impaired hypertrophy in myoblasts is improved with testosterone administration. The Journal of Steroid Biochemistry and Molecular Biology, 138, 152-161.
Bailey DP, Fairclough SJ, Savory LA, Denton SJ, Pang D, Deane CS, Kerr CJ (2012). Accelerometry-assessed sedentary behaviour and physical activity levels during the segmented school day in 10–14-year-old children: the HAPPY study. European Journal of Pediatrics, 171(12), 1805-1813.

Conferences

Gaffney CJ, Torregrossa R, Deane CS, Whiteman M, Etheridge T, Nartallo R, Neri G, Zolesi D, Ellwood RA, Cooke M, et al (2020). Commercial access for UK/ESA student experiments on board the ISS. Proceedings of the 3rd Symposium on Space Educational Activities.

Publications by year


In Press

Hewitt JE, Pollard AK, Lesanpezeshki L, Deane CS, Gaffney CJ, Etheridge T, Szewczyk NJ, Vanapalli SA (In Press). Muscle strength deficiency and mitochondrial dysfunction in a muscular dystrophy model of C. elegans and its functional response to drugs. Disease Models & Mechanisms
Laranjeiro R, Harinath G, Pollard AK, Gaffney CJ, Deane CS, Vanapalli SA, Etheridge T, Szewczyk NJ, Driscoll M (In Press). Spaceflight Affects Neuronal Morphology and Alters Transcellular Degradation of Neuronal Debris in Adult Caenorhabditis elegans.  Abstract.

2021

Sian TS, Din USU, Deane CS, Smith K, Gates A, Lund JN, Williams JP, Rueda R, Pereira SL, Phillips BE, et al (2021). Cocoa flavanols adjuvant to an oral nutritional supplement acutely enhances nutritive flow in skeletal muscle without altering leg glucose uptake kinetics in older adults. Nutrients, 13(5). Abstract.
Deane CS, Ely IA, Wilkinson DJ, Smith K, Phillips BE, Atherton PJ (2021). Dietary protein, exercise, ageing and physical inactivity: interactive influences on skeletal muscle proteostasis. Proc Nutr Soc, 80(2), 106-117. Abstract.  Author URL.
Maunder E, Bradley HE, Deane CS, Hodgson AB, Jones M, Joanisse S, Turner AM, Breen L, Philp A, Wallis GA, et al (2021). Effects of short-term graded dietary carbohydrate intake on intramuscular and whole body metabolism during moderate-intensity exercise. J Appl Physiol (1985), 131(1), 376-387. Abstract.  Author URL.
Deane CS, Gates A, Traviss-Turner GD, Wilkinson DJ, Smith K, Atherton PJ, Phillips BE (2021). Exploring the impact of COVID-19 on the willingness of older adults to participate in physiology research: views from past and potential volunteers. Applied Physiology, Nutrition, and Metabolism, 46(9), 1147-1151. Abstract.
Din USU, Sian TS, Deane CS, Smith K, Gates A, Lund JN, Williams JP, Rueda R, Pereira SL, Atherton PJ, et al (2021). Green Tea Extract Concurrent with an Oral Nutritional Supplement Acutely Enhances Muscle Microvascular Blood Flow without Altering Leg Glucose Uptake in Healthy Older Adults. Nutrients, 13(11), 3895-3895. Abstract.
Sudevan S, Muto K, Higashitani N, Hashizume T, Higashibata A, Ellwood RA, Deane CS, Rahman M, Vanapalli SA, Etheridge T, et al (2021). Loss of Contact in Space Alters Dopamine System in <i>C. elegans</i>.
Ellwood RA, Hewitt JE, Torregrossa R, Philp AM, Hardee JP, Hughes S, van de Klashorst D, Gharahdaghi N, Anupom T, Slade L, et al (2021). Mitochondrial hydrogen sulfide supplementation improves health in the C. elegans Duchenne muscular dystrophy model. Proceedings of the National Academy of Sciences, 118(9), e2018342118-e2018342118. Abstract.
Willis CRG, Deane CS (2021). Nrf2 deficiency induces skeletal muscle mitochondrial dysfunction: a proteomics/bioinformatics approach. J Physiol, 599(3), 729-730. Author URL.
Laranjeiro R, Harinath G, Pollard AK, Gaffney CJ, Deane CS, Vanapalli SA, Etheridge T, Szewczyk NJ, Driscoll M (2021). Spaceflight affects neuronal morphology and alters transcellular degradation of neuronal debris in adult Caenorhabditis elegans. iScience, 24(2). Abstract.
Bass JJ, Kazi AA, Deane CS, Nakhuda A, Ashcroft SP, Brook MS, Wilkinson DJ, Phillips BE, Philp A, Tarum J, et al (2021). The mechanisms of skeletal muscle atrophy in response to transient knockdown of the vitamin D receptor in vivo. J Physiol, 599(3), 963-979. Abstract.  Author URL.
Deane CS, Willis CRG, Phillips BE, Atherton PJ, Harries LW, Ames RM, Szewczyk NJ, Etheridge T (2021). Transcriptomic meta-analysis of disuse muscle atrophy vs. resistance exercise-induced hypertrophy in young and older humans. J Cachexia Sarcopenia Muscle, 12(3), 629-645. Abstract.  Author URL.

2020

Deane C, Bass J, Crossland H, Phillips B, Atherton P (2020). Animal, Plant, Collagen and Blended Dietary Proteins: Effects on Musculoskeletal Outcomes. Nutrients, 12(9), 2670-2670. Abstract.
Deane CS, Phillips BE, Smith K, Steele AM, Libretto T, Statton SA, Atherton PJ, Etheridge T (2020). Challenges and practical recommendations for successfully recruiting inactive, statin-free older adults to clinical trials. BMC Research Notes, 13(1). Abstract.
Gaffney CJ, Torregrossa R, Deane CS, Whiteman M, Etheridge T, Nartallo R, Neri G, Zolesi D, Ellwood RA, Cooke M, et al (2020). Commercial access for UK/ESA student experiments on board the ISS. Proceedings of the 3rd Symposium on Space Educational Activities.
Pollard AK, Gaffney CJ, Deane CS, Balsamo M, Cooke M, Ellwood RA, Hewitt JE, Mierzwa BE, Mariani A, Vanapalli SA, et al (2020). Molecular Muscle Experiment: Hardware and Operational Lessons for Future Astrobiology Space Experiments. Astrobiology, 20(8), 935-943. Abstract.  Author URL.
Willis CRG, Ames RM, Deane CS, Phillips BE, Boereboom CL, Abdulla H, Bukhari SSI, Lund JN, Williams JP, Wilkinson DJ, et al (2020). Network analysis of human muscle adaptation to aging and contraction. Aging (Albany NY), 12(1), 740-755. Abstract.  Author URL.
Bass JJ, Nakhuda A, Deane CS, Brook MS, Wilkinson DJ, Phillips BE, Philp A, Tarum J, Kadi F, Andersen D, et al (2020). Overexpression of the vitamin D receptor (VDR) induces skeletal muscle hypertrophy. Mol Metab, 42 Abstract.  Author URL.
Madrigal P, Gabel A, Villacampa A, Manzano A, Deane CS, Bezdan D, Carnero-Diaz E, Medina FJ, Hardiman G, Grosse I, et al (2020). Revamping Space-omics in Europe. Cell Systems, 11(6), 555-556.
Laranjeiro R, Harinath G, Pollard AK, Deane CS, Vanapalli SA, Etheridge T, Szewczyk NJ, Driscoll M (2020). Spaceflight Affects Neuronal Morphology and Alters Transcellular Degradation of Neuronal Debris in Adult <i>Caenorhabditis Elegans</i>.

2019

Deane C, Szewczyk N (2019). Extraterrestrial life science. Biologist, 66(4), 12-15.
Deane CS, Ames RM, Phillips BE, Weedon MN, Willis CRG, Boereboom C, Abdulla H, Bukhari SSI, Lund JN, Williams JP, et al (2019). The acute transcriptional response to resistance exercise: impact of age and contraction mode. Aging (Albany NY), 11(7), 2111-2126. Abstract.  Author URL.

2018

Dugdale HF, Hughes DC, Allan R, Deane CS, Coxon CR, Morton JP, Stewart CE, Sharples AP (2018). The role of resveratrol on skeletal muscle cell differentiation and myotube hypertrophy during glucose restriction. Molecular and Cellular Biochemistry, 444(1-2), 109-123. Abstract.
Gaffney CJ, Pollard AK, Deane CS, Cooke M, Balsamo M, Hewitt J, Vanapalli SA, Szewczyk NJ, Etheridge T, Phillips BE, et al (2018). Worms in Space for Outreach on Earth: Space Life Science Activities for the Classroom. Gravitational and Space Research, 6(2), 74-82.
Deane C, Pollard A, Cegielski J, Bass J (2018). YLS 2017: planning your first symposium – a pilot study. Physiology News(Winter 2017), 16-17.

2017

Deane CS, Wilkinson DJ, Phillips BE, Smith K, Etheridge T, Atherton PJ (2017). "Nutraceuticals" in relation to human skeletal muscle and exercise. Am J Physiol Endocrinol Metab, 312(4), E282-E299. Abstract.  Author URL.

2015

Sharples AP, Hughes DC, Deane CS, Saini A, Selman C, Stewart CE (2015). Longevity and skeletal muscle mass: the role of IGF signalling, the sirtuins, dietary restriction and protein intake. Aging Cell, 14(4), 511-523.

2013

Deane C (2013). Book Review: Sporting Times (Palgrave Pivot). Sociological Research Online, 18(3), 188-189.
Deane C (2013). Book Review: Sporting Times (Palgrave Pivot). Sociological Research Online, 18(1), 248-249.
Deane CS, Hughes DC, Sculthorpe N, Lewis MP, Stewart CE, Sharples AP (2013). Impaired hypertrophy in myoblasts is improved with testosterone administration. The Journal of Steroid Biochemistry and Molecular Biology, 138, 152-161.

2012

Bailey DP, Fairclough SJ, Savory LA, Denton SJ, Pang D, Deane CS, Kerr CJ (2012). Accelerometry-assessed sedentary behaviour and physical activity levels during the segmented school day in 10–14-year-old children: the HAPPY study. European Journal of Pediatrics, 171(12), 1805-1813.

Colleen_Deane Details from cache as at 2021-11-28 15:44:02

Refresh publications

External Engagement and Impact

Awards

MRC Skills Development Fellowship (2019)

Wellcome Trust ISSF (2019)

Association for Academic Outreach Travel Award (2019)

Alumni Funding, University of Exeter (2018)

Young Life Scientists’ Symposium (2018)

The Physiological Society Travel Award (2017) (2016) (2015) (2014)

Santander Scholarship (2014) (2013)


Committee/panel activities

British Science Association Committee Member


Conferences and invited presentations

Invited talks:

International Space Station Increment 57/58 Science Symposium (2018)


Media Coverage

Newsweek article 'What happens to the human body in space?' (2018)

BBC Spotlight TV coverage (2018)


Research networks

Early Career Research Network Representative


Workshops/Conferences organised

Bridging the physiological gap: using c.elegans to improve human skeletal muscle health, International C.elegans Conference 2019, Los Angeles, USA. (2019).

Sport and Health Sciences Conference, Exeter, UK. (2019).

Young Life Scientists’ Symposium: Frontiers in Musculoskeletal Health, Ageing and Disease, Derby, UK. (2017).

Teaching

Supervision / Group

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