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Dr Colleen Deane

Dr Colleen Deane

MRC Skills Development Fellow

 2882

 Haighton 

 

University of Exeter, St Luke's Campus, Exeter, EX1 2LU, UK

Overview

Colleen is a Medical Research Council Skills Development Fellow, utilising a multi-omics approach to understand the mechanisms underlying age-related muscle atrophy and hypertrophy. During this fellowship, Colleen is developing her computational modelling skills to complement her strong training background in skeletal muscle metabolic/molecular phsiology. 

Prior to being awarded her fellowship, Colleen was working as a post-doctoral research fellow under the supervision of Dr. Timothy Etheridge. During this time, Colleen worked on two main projects that were; i) investigaing whether NAD+ supplementation improved skeletal muscle mitochondrial function and physical capacity in older adults and, ii) establishing molecular mechanisms of and countermeasures to muscle decline in space. 

Colleen completed her Ph.D. in 2017, which investigated the metabolic and molecular mechanisms regulating age-related declines in human skeletal muscle regenerative capacity. Prior to her Ph.D., Colleen completed an MSc in Physical Activity, Nutrition and Health Promotion and a BSc in Sport and Exercise Science. 

 

 

Qualifications

Ph.D., MSc, BSc.

Career

Ph.D. Exploring Metabolic and Molecular Mechanisms Regulating Age-Related Declines in Human Skeletal Muscle Regenerative Capacity

MSc Physical Activity, Nutrition and Health Promotion 

BSc Sport and Exercise Science 

Research

Research interests

Skeletal muscle remodelling in the context of ageing, exercise, disuse and nutrition. 

Research projects

I am currently an Medical Research Council Skills Development Fellow, utilising a multi-omics approach to understand the mechanisms underlying age-related muscle atrophy and hypertrophy. 

Publications

Key publications | Publications by category | Publications by year

Publications by category


Journal articles

Hewitt JE, Pollard AK, Lesanpezeshki L, Deane CS, Gaffney CJ, Etheridge T, Szewczyk NJ, Vanapalli SA (In Press). Muscle strength deficiency and mitochondrial dysfunction in a muscular dystrophy model of C. elegans and its functional response to drugs. Disease Models & Mechanisms Full text.
Deane CS, Phillips BE, Smith K, Steele AM, Libretto T, Statton SA, Atherton PJ, Etheridge T (2020). Challenges and practical recommendations for successfully recruiting inactive, statin-free older adults to clinical trials. BMC Research Notes, 13(1). Full text.
Pollard AK, Gaffney CJ, Deane CS, Balsamo M, Cooke M, Ellwood RA, Hewitt JE, Mierzwa BE, Mariani A, Vanapalli SA, et al (2020). Molecular Muscle Experiment: Hardware and Operational Lessons for Future Astrobiology Space Experiments. Astrobiology Abstract.  Author URL.
Willis CRG, Ames RM, Deane CS, Phillips BE, Boereboom CL, Abdulla H, Bukhari SSI, Lund JN, Williams JP, Wilkinson DJ, et al (2020). Network analysis of human muscle adaptation to aging and contraction. Aging (Albany NY), 12(1), 740-755. Abstract.  Author URL.  Full text.
Deane C, Szewczyk N (2019). Extraterrestrial life science. Biologist, 66(4), 12-15. Full text.
Deane CS, Ames RM, Phillips BE, Weedon MN, Willis CRG, Boereboom C, Abdulla H, Bukhari SSI, Lund JN, Williams JP, et al (2019). The acute transcriptional response to resistance exercise: impact of age and contraction mode. Aging (Albany NY), 11(7), 2111-2126. Abstract.  Author URL.  Full text.
Dugdale HF, Hughes DC, Allan R, Deane CS, Coxon CR, Morton JP, Stewart CE, Sharples AP (2018). The role of resveratrol on skeletal muscle cell differentiation and myotube hypertrophy during glucose restriction. Molecular and Cellular Biochemistry, 444(1-2), 109-123. Abstract.
Deane CS, Wilkinson DJ, Phillips BE, Smith K, Etheridge T, Atherton PJ (2017). "Nutraceuticals" in relation to human skeletal muscle and exercise. Am J Physiol Endocrinol Metab, 312(4), E282-E299. Abstract.  Author URL.  Full text.
Sharples AP, Hughes DC, Deane CS, Saini A, Selman C, Stewart CE (2015). Longevity and skeletal muscle mass: the role of IGF signalling, the sirtuins, dietary restriction and protein intake. Aging Cell, 14(4), 511-523.
Deane CS, Hughes DC, Sculthorpe N, Lewis MP, Stewart CE, Sharples AP (2013). Impaired hypertrophy in myoblasts is improved with testosterone administration. The Journal of Steroid Biochemistry and Molecular Biology, 138, 152-161.
Bailey DP, Fairclough SJ, Savory LA, Denton SJ, Pang D, Deane CS, Kerr CJ (2012). Accelerometry-assessed sedentary behaviour and physical activity levels during the segmented school day in 10–14-year-old children: the HAPPY study. European Journal of Pediatrics, 171(12), 1805-1813.

Publications by year


In Press

Hewitt JE, Pollard AK, Lesanpezeshki L, Deane CS, Gaffney CJ, Etheridge T, Szewczyk NJ, Vanapalli SA (In Press). Muscle strength deficiency and mitochondrial dysfunction in a muscular dystrophy model of C. elegans and its functional response to drugs. Disease Models & Mechanisms Full text.

2020

Deane CS, Phillips BE, Smith K, Steele AM, Libretto T, Statton SA, Atherton PJ, Etheridge T (2020). Challenges and practical recommendations for successfully recruiting inactive, statin-free older adults to clinical trials. BMC Research Notes, 13(1). Full text.
Pollard AK, Gaffney CJ, Deane CS, Balsamo M, Cooke M, Ellwood RA, Hewitt JE, Mierzwa BE, Mariani A, Vanapalli SA, et al (2020). Molecular Muscle Experiment: Hardware and Operational Lessons for Future Astrobiology Space Experiments. Astrobiology Abstract.  Author URL.
Willis CRG, Ames RM, Deane CS, Phillips BE, Boereboom CL, Abdulla H, Bukhari SSI, Lund JN, Williams JP, Wilkinson DJ, et al (2020). Network analysis of human muscle adaptation to aging and contraction. Aging (Albany NY), 12(1), 740-755. Abstract.  Author URL.  Full text.

2019

Deane C, Szewczyk N (2019). Extraterrestrial life science. Biologist, 66(4), 12-15. Full text.
Deane CS, Ames RM, Phillips BE, Weedon MN, Willis CRG, Boereboom C, Abdulla H, Bukhari SSI, Lund JN, Williams JP, et al (2019). The acute transcriptional response to resistance exercise: impact of age and contraction mode. Aging (Albany NY), 11(7), 2111-2126. Abstract.  Author URL.  Full text.

2018

Dugdale HF, Hughes DC, Allan R, Deane CS, Coxon CR, Morton JP, Stewart CE, Sharples AP (2018). The role of resveratrol on skeletal muscle cell differentiation and myotube hypertrophy during glucose restriction. Molecular and Cellular Biochemistry, 444(1-2), 109-123. Abstract.

2017

Deane CS, Wilkinson DJ, Phillips BE, Smith K, Etheridge T, Atherton PJ (2017). "Nutraceuticals" in relation to human skeletal muscle and exercise. Am J Physiol Endocrinol Metab, 312(4), E282-E299. Abstract.  Author URL.  Full text.

2015

Sharples AP, Hughes DC, Deane CS, Saini A, Selman C, Stewart CE (2015). Longevity and skeletal muscle mass: the role of IGF signalling, the sirtuins, dietary restriction and protein intake. Aging Cell, 14(4), 511-523.

2013

Deane CS, Hughes DC, Sculthorpe N, Lewis MP, Stewart CE, Sharples AP (2013). Impaired hypertrophy in myoblasts is improved with testosterone administration. The Journal of Steroid Biochemistry and Molecular Biology, 138, 152-161.

2012

Bailey DP, Fairclough SJ, Savory LA, Denton SJ, Pang D, Deane CS, Kerr CJ (2012). Accelerometry-assessed sedentary behaviour and physical activity levels during the segmented school day in 10–14-year-old children: the HAPPY study. European Journal of Pediatrics, 171(12), 1805-1813.

Colleen_Deane Details from cache as at 2020-07-07 03:54:27

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External Engagement and Impact

Awards

MRC Skills Development Fellowship (2019)

Wellcome Trust ISSF (2019)

Association for Academic Outreach Travel Award (2019)

Alumni Funding, University of Exeter (2018)

Young Life Scientists’ Symposium (2018)

The Physiological Society Travel Award (2017) (2016) (2015) (2014)

Santander Scholarship (2014) (2013)


Committee/panel activities

British Science Association Committee Member


Conferences and invited presentations

Invited talks:

International Space Station Increment 57/58 Science Symposium (2018)


Media Coverage

Newsweek article 'What happens to the human body in space?' (2018)

BBC Spotlight TV coverage (2018)


Research networks

Early Career Research Network Representative


Workshops/Conferences organised

Bridging the physiological gap: using c.elegans to improve human skeletal muscle health, International C.elegans Conference 2019, Los Angeles, USA. (2019).

Sport and Health Sciences Conference, Exeter, UK. (2019).

Young Life Scientists’ Symposium: Frontiers in Musculoskeletal Health, Ageing and Disease, Derby, UK. (2017).

Teaching

Supervision / Group

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