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Shatavari - postmenopausal bone and muscle health

This study is examining whether a dietary supplement called shatavari improves muscle and bone health in postmenopausal women. Shatavari, has been traditionally used in ayurvedic medicine to support women’s health, but has not been well studied. The decreased oestrogen production at the menopause precipitates sharp declines in bone mineral density and muscle strength. Shatavari is known to contain phytoestrogenic (oestrogen-like) compounds that are capable of binding to the oestrogen receptor, therefore it may be a useful alternative to HRT.

This work is using a combination of in vivo and in vitro techniques to examine the effect of shatavari on bone and muscle health. These include measuring serum markers of bone turnover and muscle protein turnover. We are also using primary human osteoblast, osteoclast and myogenic cultures to determine the effect of shatavari on bone turnover and myogenic activity.  

This work is funded by Pukka Herbs and is being carried out by Dr Mary O’Leary and Prof Jo Bowtell