C. elegans projects
Clinical trials into optimising muscle health
As a group we are always considering the human application of our work. We therefore conduct human clinical trials that directly forward-translate our findings from fundamental research in C. elegans or that explore the mechanisms of muscle maintenance across the lifespan and/or the efficacy of new exercise and drug interventions. For example, ongoing research projects include:
- Examining the efficacy of NAD+ precursors for improving muscle health in older people.
- Investigating the effects of nicotinamide riboside supplementation plus exercise training for muscle health in younger and older people.
- Establishing predictive biosignatures of individual responsiveness to environmental stimuli, including exercise training.
- Exploring mechanisms of early exercise habituation in untrained people after uphill versus downhill running.
- Establishing whether the molecules that regulate muscle growth are the same as those controlling muscle loss.
Funded by the Dunhill Medical Trust, the Medical Research Council, the Biotechnology and Biological Sciences Research Council (BBSRC) and the Wellcome Trust.