Promoting healthy ageing using C. elegans

C. elegans is a small (1 mm) worm that offers several practical and scientific advantages that make it an excellent model of human ageing, and of muscle health.

Using a range of genetic and molecular techniques, our lab uses C. elegans in several research projects, including:

• High-throughout screen of novel drug compounds using our new microfluidic culturing device, the NemaLife (in collaboration with Prof. Siva Vanapalli, Texas Tech University, US).
• Establishing the efficacy and mechanisms of mitochondrial hydrogen sulfide for improving health across the lifespan.
• Investigating novel therapeutics for primary mitochondrial diseases.
• Examining the causes of and new therapeutics for Duchenne Muscular Dystrophy.

Funding

Funded by the Biotechnology and Biological Sciences Research Council, the US Army and the Northcott Devon Medical Foundation.