The impact of acute and chronic nutritional interventions on insulin sensitivity
A reduction in skeletal muscle insulin sensitivity occurs with age and obesity and is a major risk factor for type 2 diabetes, one of the biggest health concerns in the developed world.
Current projects are focused on how human skeletal muscle becomes insulin resistant, inflexibility in the ability to switch between carbohydrate and fat metabolism, and the role of nutrition (e.g. branch chain amino acids, carnitine, mycoprotein) with age, obesity and overfeeding, type 2 diabetes, and Crohn’s disease.
We also developing acute and chronic nutritional strategies to reverse the loss of insulin sensitivity, such as L-carnitine, reducing dietary branch chain amino acid content, and novel protein and fibre combinations.