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The development of insulin resistance and anabolic resistance during muscle disuse: what is the role of fuel integration?

Skeletal muscle atrophy, which occurs during short-term disuse, is thought to be due to the development of anabolic resistance of protein metabolism and insulin resistance of glucose metabolism, although their cause is currently unknown.

This Wellcome Trust-funded fellowship to Dr Marlou Dirks uses state-of-the-art in vivo metabolic techniques, including the arteriovenous-venous forearm balance technique combined with stable isotope amino acid infusion under hyperinsulinaemic-euglycaemic-hyperaminoacidaemic conditions, to investigate the impact of altered muscle substrate availability on the development of insulin resistance and anabolic resistance during short periods of muscle disuse.

As such, this fellowship will gain important insight in the roles of muscle disuse and nutrition in muscle health, and can be used to develop targeted interventions to preserve muscle mass and health during disuse.