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Professor Timothy Etheridge

Professor Timothy Etheridge


 Not Known

 Richards Building RB112


Richard's Building, University of Exeter, St Luke's Campus, Heavitree Road, Exeter, EX1 2LU, UK




Journal articles

Etheridge T (In Press). Commentaries on viewpoint: a call for research to assess and promote functional resilience in astronaut crews.
Etheridge T (In Press). Fluid dynamics alter Caenorhabditis elegans body length via neuromuscular signaling with TGF-β/DBL-1.
Hewitt JE, Pollard AK, Lesanpezeshki L, Deane CS, Gaffney CJ, Etheridge T, Szewczyk NJ, Vanapalli SA (In Press). Muscle strength deficiency and mitochondrial dysfunction in a muscular dystrophy model of C. elegans and its functional response to drugs. Disease Models & Mechanisms
Etheridge T, Atherton P, Szewczyk N, Phillips B, Smith K, Wilkinson D, Bass J, Ames R, Deane C, Willis C, et al (In Press). Transcriptomic adaptation during skeletal muscle habituation to eccentric or concentric exercise training. Scientific Reports
Slade L, Deane CS, Szewczyk NJ, Etheridge T, Whiteman M (2024). Hydrogen sulfide supplementation as a potential treatment for primary mitochondrial diseases. Pharmacol Res, 203 Abstract.  Author URL.
Cope H, Deane C, Szewczyk N, Etheridge T, Williams P, Willis C (2023). A Data Collection Programme for Improving Healthcare in UK Human Spaceflight Ventures. Journal of the British Interplanetary Society, 76(6), 213-220.
Baumann CW, Deane CS, Etheridge T, Szewczyk NJ, Willis CRG, Lowe DA (2023). Adaptability to eccentric exercise training is diminished with age in female mice. J Appl Physiol (1985), 135(5), 1135-1145. Abstract.  Author URL.
Manni E, Jeffery N, Chambers D, Slade L, Etheridge T, Harries LW (2023). An evaluation of the role of miR-361-5p in senescence and systemic ageing. Experimental Gerontology, 174, 112127-112127.
Slade L, Bollen SE, Bass JJ, Phillips BE, Smith K, Wilkinson DJ, Szewczyk NJ, Atherton PJ, Etheridge T (2023). Bisphosphonates attenuate age-related muscle decline in Caenorhabditis elegans. J Cachexia Sarcopenia Muscle, 14(6), 2613-2622. Abstract.  Author URL.
Scott A, Willis CRG, Muratani M, Higashitani A, Etheridge T, Szewczyk NJ, Deane CS (2023). Caenorhabditis elegans in microgravity: an omics perspective. iScience, 26(7).
Kim B-S, Alcantara AV, Moon J-H, Higashitani A, Higashitani N, Etheridge T, Szewczyk NJ, Deane CS, Gaffney CJ, Higashibata A, et al (2023). Comparative Analysis of Muscle Atrophy During Spaceflight, Nutritional Deficiency and Disuse in the Nematode Caenorhabditis elegans. International Journal of Molecular Sciences, 24(16).
Manzano A, Weging S, Bezdan D, Borg J, Cahill T, Carnero-Diaz E, Cope H, Deane CS, Etheridge T, Giacomello S, et al (2023). Enhancing European capabilities for application of multi-omics studies in biology and biomedicine space research. iScience, 26(9).
Vintila AR, Slade L, Cooke M, Willis CRG, Torregrossa R, Rahman M, Anupom T, Vanapalli SA, Gaffney CJ, Gharahdaghi N, et al (2023). Mitochondrial sulfide promotes life span and health span through distinct mechanisms in developing versus adult treated Caenorhabditis elegans. Proc Natl Acad Sci U S A, 120(32). Abstract.  Author URL.
Deane CS, Phillips BE, Willis CRG, Wilkinson DJ, Smith K, Higashitani N, Williams JP, Szewczyk NJ, Atherton PJ, Higashitani A, et al (2023). Proteomic features of skeletal muscle adaptation to resistance exercise training as a function of age. Geroscience, 45(3), 1271-1287. Abstract.  Author URL.
Soni P, Edwards H, Anupom T, Rahman M, Lesanpezeshki L, Blawzdziewicz J, Cope H, Gharahdaghi N, Scott D, Toh LS, et al (2023). Spaceflight Induces Strength Decline in Caenorhabditis elegans. Cells, 12(20). Abstract.  Author URL.
Clark BC, Grooms DR, Etheridge T, Wilkinson DJ, Zhu S, Arnold WD, Szewczyk NJ (2022). Editorial: Integrative Physiology of Common Chronic Musculoskeletal Disorders. Frontiers in Physiology, 13
Sudevan S, Muto K, Higashitani N, Hashizume T, Higashibata A, Ellwood RA, Deane CS, Rahman M, Vanapalli SA, Etheridge T, et al (2022). Loss of physical contact in space alters the dopamine system in C. elegans. iScience, 25(2), 103762-103762.
Fernandez-Gonzalo R, Willis CRG, Etheridge T, Deane CS (2022). RNA-Sequencing Muscle Plasticity to Resistance Exercise Training and Disuse in Youth and Older Age. Physiologia, 2(4), 164-179.
Cope H, Willis CRG, MacKay MJ, Rutter LA, Toh LS, Williams PM, Herranz R, Borg J, Bezdan D, Giacomello S, et al (2022). Routine omics collection is a golden opportunity for European human research in space and analog environments. Patterns, 3(10). Abstract.
Deane CS, Deane CS, Borg J, Cahill T, Carnero-Diaz E, Etheridge T, Hardiman G, Leys N, Madrigal P, Manzano A, et al (2022). Space omics research in Europe: Contributions, geographical distribution and ESA member state funding schemes. iScience, 25(3).
Ellwood RA, Slade L, Lewis J, Torregrossa R, Sudevan S, Piasecki M, Whiteman M, Etheridge T, Szewczyk NJ (2022). Sulfur amino acid supplementation displays therapeutic potential in a C. elegans model of Duchenne muscular dystrophy. Commun Biol, 5(1). Abstract.  Author URL.
Shamsul A, Sinclair G, Bolliand A, Chabi A, Martinez M, Zalasiewicz M, Cullen D, Cooke M, Szewczyk N, Etheridge T, et al (2021). A VERSATILE MINIATURISED HARDWARE PLATFORM TO ENABLE BIOSCIENCE RESEARCH IN SPACE. JBIS - Journal of the British Interplanetary Society, 74(10), 386-395. Abstract.
Ellwood RA, Hewitt JE, Torregrossa R, Philp AM, Hardee JP, Hughes S, van de Klashorst D, Gharahdaghi N, Anupom T, Slade L, et al (2021). Mitochondrial hydrogen sulfide supplementation improves health in the. <i>C. elegans</i>. Duchenne muscular dystrophy model. Proceedings of the National Academy of Sciences, 118(9). Abstract.
Laranjeiro R, Harinath G, Pollard AK, Gaffney CJ, Deane CS, Vanapalli SA, Etheridge T, Szewczyk NJ, Driscoll M (2021). Spaceflight affects neuronal morphology and alters transcellular degradation of neuronal debris in adult Caenorhabditis elegans. iScience, 24(2). Abstract.
Fox BC, Slade L, Torregrossa R, Pacitti D, Szabo C, Etheridge T, Whiteman M (2021). The mitochondria-targeted hydrogen sulfide donor AP39 improves health and mitochondrial function in a C. elegans primary mitochondrial disease model. J Inherit Metab Dis, 44(2), 367-375. Abstract.  Author URL.
Willis CRG, Gallagher IJ, Wilkinson DJ, Brook MS, Bass JJ, Phillips BE, Smith K, Etheridge T, Stokes T, McGlory C, et al (2021). Transcriptomic links to muscle mass loss and declines in cumulative muscle protein synthesis during short-term disuse in healthy younger humans. FASEB J, 35(9). Abstract.  Author URL.
Deane CS, Willis CRG, Phillips BE, Atherton PJ, Harries LW, Ames RM, Szewczyk NJ, Etheridge T (2021). Transcriptomic meta-analysis of disuse muscle atrophy vs. resistance exercise-induced hypertrophy in young and older humans. J Cachexia Sarcopenia Muscle, 12(3), 629-645. Abstract.  Author URL.
Deane CS, Phillips BE, Smith K, Steele AM, Libretto T, Statton SA, Atherton PJ, Etheridge T (2020). Challenges and practical recommendations for successfully recruiting inactive, statin-free older adults to clinical trials. BMC Research Notes, 13(1). Abstract.
Willis CRG, Szewczyk NJ, Costes SV, Udranszky IA, Reinsch SS, Etheridge T, Conley CA (2020). Comparative Transcriptomics Identifies Neuronal and Metabolic Adaptations to Hypergravity and Microgravity in Caenorhabditis elegans. iScience, 23(12). Abstract.
Pollard AK, Gaffney CJ, Deane CS, Balsamo M, Cooke M, Ellwood RA, Hewitt JE, Mierzwa BE, Mariani A, Vanapalli SA, et al (2020). Molecular Muscle Experiment: Hardware and Operational Lessons for Future Astrobiology Space Experiments. Astrobiology, 20(8), 935-943. Abstract.  Author URL.
Willis CRG, Ames RM, Deane CS, Phillips BE, Boereboom CL, Abdulla H, Bukhari SSI, Lund JN, Williams JP, Wilkinson DJ, et al (2020). Network analysis of human muscle adaptation to aging and contraction. Aging (Albany NY), 12(1), 740-755. Abstract.  Author URL.
Gaffney CJ, Pollard AK, Deane CS, Cooke M, Balsamo M, Hewitt J, Vanapalli SA, Szewczyk NJ, Etheridge T, Phillips BE, et al (2020). Worms in Space for Outreach on Earth: Space Life Science Activities for the Classroom. Gravitational and Space Research, 6(2), 74-82.
Sudevan S, Takiura M, Kubota Y, Higashitani N, Cooke M, Ellwood RA, Etheridge T, Szewczyk NJ, Higashitani A (2019). Mitochondrial dysfunction causes Ca2+ overload and ECM degradation-mediated muscle damage in C. elegans. FASEB J, 33(8), 9540-9550. Abstract.  Author URL.
Deane CS, Ames RM, Phillips BE, Weedon MN, Willis CRG, Boereboom C, Abdulla H, Bukhari SSI, Lund JN, Williams JP, et al (2019). The acute transcriptional response to resistance exercise: impact of age and contraction mode. Aging (Albany NY), 11(7), 2111-2126. Abstract.  Author URL.
Etheridge T, Atherton PJ (2018). Food texture: a potential dietary consideration for obesity prevention?. Exp Physiol, 103(10), 1298-1299.  Author URL.
Deane CS, Wilkinson DJ, Phillips BE, Smith K, Etheridge T, Atherton PJ (2017). "Nutraceuticals" in relation to human skeletal muscle and exercise. Am J Physiol Endocrinol Metab, 312(4), E282-E299. Abstract.  Author URL.
Etheridge T, Higashibata A, Hashizume T, Nemoto K, Higashitani N, Mori C, Harada S, Sugimoto T, Szewczyk N, Baba S, et al (2016). Microgravity elicits reproducible alterations in cytoskeletal and metabolic gene and protein expression in space-flown Caenorhabditis elegans. npj Microgravity, 2, n/a-n/a.
Atherton PJ, Phillips BE, Brook MS, Wilkinson DJ, Smith K, Etheridge TE, Miller BF, Hamilton KL, Burd NA, Beals JW, et al (2015). Commentaries on Viewpoint: What is the relationship between acute measure of muscle protein synthesis and changes in muscle mass?. J Appl Physiol (1985), 118(4), 498-503.  Author URL.
Etheridge T, Rahman M, Gaffney CJ, Shaw D, Shephard F, Magudia J, Solomon DE, Milne T, Blawzdziewicz J, Constantin-Teodosiu D, et al (2015). The integrin-adhesome is required to maintain muscle structure, mitochondrial ATP production, and movement forces in Caenorhabditis elegans. FASEB J, 29(4), 1235-1246. Abstract.  Author URL.
Wilkinson DJ, Hossain T, Hill DS, Phillips BE, Crossland H, Williams J, Loughna P, Churchward-Venne TA, Breen L, Phillips SM, et al (2013). Effects of leucine and its metabolite β-hydroxy-β-methylbutyrate on human skeletal muscle protein metabolism. J Physiol, 591(11), 2911-2923. Abstract.  Author URL.
Higashibata A, Higashitani N, Imamizo-Sato M, Hashizume T, Etheridge T, Szewczyk N, Higashitani A, Ishioka N (2013). Space Flight Induces Reduction of Paramyosin and Troponin T: Proteomic Analysis of Space-Flown Caenorhabditis elegans. Current Biotechnology, 999(999), 19-24.
Higashibata A, Higashitani N, Imamizo-Sato M, Hashizume T, Etheridge T, Szewczyk N, Higashitani A, Ishioka N (2013). Space Flight Induces Reduction of Paramyosin and Troponin T: Proteomic Analysis of Space-Flown Caenorhabditis elegans. Current Biotechnology, 2(3), 262-271.
Etheridge T, Oczypok EA, Lehmann S, Fields BD, Shephard F, Jacobson LA, Szewczyk NJ (2012). Calpains Mediate Integrin Attachment Complex Maintenance of Adult Muscle in Caenorhabditis elegans. PLoS Genetics, 8(1), e1002471-e1002471.
Etheridge T, Atherton PJ, Wilkinson D, Selby A, Rankin D, Webborn N, Smith K, Watt PW (2011). Effects of hypoxia on muscle protein synthesis and anabolic signaling at rest and in response to acute resistance exercise. American Journal of Physiology-Endocrinology and Metabolism, 301(4), E697-E702. Abstract.
Oczypok EA, Etheridge T, Freeman J, Stodieck L, Johnsen R, Baillie D, Szewczyk NJ (2011). Remote automated multi-generational growth and observation of an animal in low Earth orbit. Journal of the Royal Society Interface, 9(68), 596-599. Abstract.
Etheridge T, Nemoto K, Hashizume T, Mori C, Sugimoto T, Suzuki H, Fukui K, Yamazaki T, Higashibata A, Szewczyk NJ, et al (2011). The Effectiveness of RNAi in Caenorhabditis elegans is Maintained during Spaceflight. PLoS ONE, 6(6), e20459-e20459.
Etheridge T, Nemoto K, Hashizume T, Mori C, Sugimoto T, Suzuki H, Fukui K, Yamazaki T, Higashibata A, Szewczyk NJ, et al (2011). The next phase of life-sciences spaceflight research: Harnessing the power of functional genomics. Commun Integr Biol, 4(6), 668-669. Abstract.  Author URL.
Atherton PJ, Etheridge T, Watt P, Wilkinson D, Rankin D, Smith K, Rennie M (2011). The “muscle‐full” anabolic set‐point in response to oral protein is lower in muscle of older men than in young men. The FASEB Journal, 25(S1), 1104.7-1104.7.
Atherton PJ, Smith K, Etheridge T, Rankin D, Rennie MJ (2010). Distinct anabolic signalling responses to amino acids in C2C12 skeletal muscle cells. Amino Acids, 38(5), 1533-1539. Abstract.  Author URL.
Etheridge T, Szewczyk NJ (2010). Modelling the negative regulation of muscle protein degradation by attachment complexes using C. elegans. The FASEB Journal, 24(S1), 1046.7-1046.7.
Atherton PJ, Etheridge T, Watt PW, Wilkinson D, Selby A, Rankin D, Smith K, Rennie MJ (2010). Muscle full effect after oral protein: time-dependent concordance and discordance between human muscle protein synthesis and mTORC1 signaling. The American Journal of Clinical Nutrition, 92(5), 1080-1088.
Atherton PJ, Etheridge T, Watt PW, Wilkinson D, Selby AL, Rankin D, Smith K, Rennie MJ (2010). The “muscle‐full” effect after oral protein: time‐dependent concordance/discordance between muscle protein synthesis (MPS) and mammalian target of rapamycin (mTOR)‐associated signaling. The FASEB Journal, 24(S1), 331.1-331.1.
Higashitani A, Hashizume T, Sugimoto T, Mori C, Nemoto K, Etheridge T, Higashitani N, Takanami T, Suzuki H, Fukui K, et al (2009). C. elegans RNAi space experiment (CERISE) in Japanese Experiment Module KIBO. Biological Sciences in Space, 23(4), 183-187.
Etheridge T, Philp A, Watt PW (2008). A single protein meal increases recovery of muscle function following an acute eccentric exercise bout. Appl Physiol Nutr Metab, 33(3), 483-488. Abstract.  Author URL.
Philp A, Etheridge T, Watt PW (2006). Post exercise protein ingestion does not attenuate delayed onset muscle soreness. The FASEB Journal, 20(5), lb26-lb26.


Etheridge T, Atherton PJ (2023). Aspekte der Ernährung bei kombiniertem Ausdauer- und Krafttraining. In  (Ed) Kombiniertes Ausdauer- und Krafttraining, Springer Nature, 259-284.
Willis CRG, Deane CS, Etheridge T (2023). Myokines, Measurement, and Technical Considerations. In  (Ed) Neuromuscular Assessments of Form and Function, Springer Nature, 215-241.
Etheridge T, Atherton PJ (2018). Nutritional Considerations for Concurrent Training. In  (Ed) Concurrent Aerobic and Strength Training, Springer Nature, 229-252.


Gaffney CJ, Torregrossa R, Deane CS, Whiteman M, Etheridge T, Nartallo R, Neri G, Zolesi D, Ellwood RA, Cooke M, et al (2020). Commercial access for UK/ESA student experiments on board the ISS. Proceedings of the 3rd Symposium on Space Educational Activities.
Shamsul A, Cullen D, Etheridge T, Cooke M, Millard T (2019). BAMMsat recent development: a bioCubeSat hardware platform to enable biological studies in space. Abstract.
Etheridge T, Gaffney C, Szewczyk N, Torregrossa R, Wood ME, Whiteman M (2017). Mitochondria-targeting hydrogen sulfide donors prolong healthspan: lifespan ratio in <i>Caenorhabditis elegans</i>.  Author URL.

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